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M6545

Sigma-Aldrich

米托蒽醌 二盐酸盐

≥97% (HPLC)

Synonym(s):
1,4-二羟基-5,8-双-[[2-[(2-羟乙基)氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐
Empirical Formula (Hill Notation):
C22H28N4O6 · 2HCl
CAS Number:
Molecular Weight:
517.40
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.25

质量水平

100

测定

≥97% (HPLC)

SMILES string

Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12

InChI

1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

InChI key

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

Gene Information

human ... TOP2A(7153)

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应用

盐酸米托蒽醌已用于:
  • 诱导细胞表达钙网蛋白
  • 作为遗传毒素剂
  • 作为拓扑异构酶抑制剂

包装

10, 50 mg in glass bottle

生化/生理作用

米托蒽醌是一种细胞抑制性蒽二酮,可嵌入 DNA 中,通过稳定拓扑异构酶 II 与 DNA 的可裂解复合物,增加双链断裂的发生率。米托蒽醌还表现出广泛的免疫抑制活性,抑制各类淋巴细胞增殖并诱导抗原提呈 T 细胞凋亡。它在临床上用作抗白血病和实体瘤的化疗药物以及多发性硬化症的免疫系统调节剂。

象形图

Health hazard

警示用语:

Danger

危险声明

预防措施声明

危险分类

Muta. 1B - Repr. 1B

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificate of Analysis

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Certificate of Origin

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