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Merck
CN

M6545

米托蒽醌 二盐酸盐

≥97% (HPLC)

别名:

1,4-二羟基-5,8-双-[[2-[（2-羟乙基）氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐

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关于此项目

经验公式（希尔记法）:
C22H28N4O6 · 2HCl
化学文摘社编号:
70476-82-3
分子量:
517.40
NACRES:
NA.25
PubChem Substance ID:
24278562
UNSPSC Code:
12352005
EC Number:
274-619-1
MDL number:
MFCD00242943
Assay:
≥97% (HPLC)
Quality level:
100

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InChI key

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

InChI

1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

SMILES string

Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12

assay

≥97% (HPLC)

Quality Level

100

Gene Information

human ... TOP2A(7153)

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Application

盐酸米托蒽醌已用于：
  • 诱导细胞表达钙网蛋白
  • 作为遗传毒素剂
  • 作为拓扑异构酶抑制剂

Biochem/physiol Actions

米托蒽醌是一种细胞抑制性蒽二酮，可嵌入 DNA 中，通过稳定拓扑异构酶 II 与 DNA 的可裂解复合物，增加双链断裂的发生率。米托蒽醌还表现出广泛的免疫抑制活性，抑制各类淋巴细胞增殖并诱导抗原提呈 T 细胞凋亡。它在临床上用作抗白血病和实体瘤的化疗药物以及多发性硬化症的免疫系统调节剂。

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H340,H360

Hazard Classifications

Muta. 1B - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX5450
MKCT3297
MKCQ3047
MKCM8540
MKCL5878

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DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

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