M6680
Se-（甲基）硒代半胱氨酸 盐酸盐
≥95% (TLC), apoptosis inducer
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关于此项目
经验公式（希尔记法）:
C4H9NO2Se · HCl
化学文摘社编号:
分子量:
218.54
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32
产品名称
Se-（甲基）硒代半胱氨酸 盐酸盐, ≥95% (TLC)
质量水平
方案
≥95% (TLC)
储存温度
−20°C
SMILES字符串
Cl.C[Se]C[C@H](N)C(O)=O
InChI
1S/C4H9NO2Se.ClH/c1-8-2-3(5)4(6)7;/h3H,2,5H2,1H3,(H,6,7);1H/t3-;/m0./s1
InChI key
JMPVTFHGWJDSDV-DFWYDOINSA-N
一般描述
硒 (Se)-（甲基）硒代半胱氨酸 (MeSeCys) 是硒代半胱氨酸的甲基化产物，该反应由 双叶黄芪中的硒代半胱氨酸甲基转移酶 (SMT) 催化 。
应用
Se-（甲基）硒代半胱氨酸盐酸盐已被用作荧光-XANES（X 射线吸收近边缘光谱学）成像的标准。
生化/生理作用
硒 (Se)-（甲基）硒代半胱氨酸是治疗乳腺癌的有效化疗药物。体内 L-Se-甲基硒代半胱氨酸生成甲基硒 的增加 可改变细胞的氧化还原状态并氧化触发细胞凋亡。它还可能抑制大鼠乳腺肿瘤的形成。
硒-（甲基）硒代半胱氨酸是一种化学预防剂，可阻断癌前期乳腺病变的细胞周期进程和增殖，并诱导培养的癌细胞系凋亡。
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
In situ speciation and distribution of toxic selenium in hydrated roots of cowpea.
Wang P
Plant Physiology, 163(1), 407-418 (2013)
Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase.
Ellis DR
BMC plant biology, 4:1 (2004)
Laurent Ouerdane et al.
Metallomics : integrated biometal science, 12(12), 2032-2048 (2020-11-10)
Low molecular weight selenium containing metabolites in the leaves of the selenium hyperaccumulator Cardamine violifolia (261 mg total Se per kg d.w.) were targeted in this study. One dimensional cation exchange chromatography coupled to ICP-MS was used for purification and
Selenium rescues orbital fibroblasts from cell death induced by hydrogen peroxide: another molecular basis for the effects of selenium in graves' orbitopathy.
Giovanna Rotondo Dottore et al.
Endocrine, 58(2), 386-389 (2017-01-18)
Zuzana Čadková et al.
Metallomics : integrated biometal science, 10(4), 579-586 (2018-03-21)
Se-Enriched defatted rapeseed (Se-DRS), a by-product of rapeseed oil production, is high in Se. This study aimed to detect possible changes in Se-metabolism after Se-DRS consumption and to assess its suitability as a Se supplement in monogaster feed. In this
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
Chromatograms
application for HPLC
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