M6680
Se-（甲基）硒代半胱氨酸 盐酸盐
≥95% (TLC), apoptosis inducer
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关于此项目
经验公式（希尔记法）:
C4H9NO2Se · HCl
化学文摘社编号:
分子量:
218.54
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
Se-（甲基）硒代半胱氨酸 盐酸盐, ≥95% (TLC)
SMILES string
Cl.C[Se]C[C@H](N)C(O)=O
InChI
1S/C4H9NO2Se.ClH/c1-8-2-3(5)4(6)7;/h3H,2,5H2,1H3,(H,6,7);1H/t3-;/m0./s1
InChI key
JMPVTFHGWJDSDV-DFWYDOINSA-N
assay
≥95% (TLC)
storage temp.
−20°C
Quality Level
General description
硒 (Se)-（甲基）硒代半胱氨酸 (MeSeCys) 是硒代半胱氨酸的甲基化产物，该反应由 双叶黄芪中的硒代半胱氨酸甲基转移酶 (SMT) 催化 。
Application
Se-（甲基）硒代半胱氨酸盐酸盐已被用作荧光-XANES（X 射线吸收近边缘光谱学）成像的标准。
Biochem/physiol Actions
硒 (Se)-（甲基）硒代半胱氨酸是治疗乳腺癌的有效化疗药物。体内 L-Se-甲基硒代半胱氨酸生成甲基硒 的增加 可改变细胞的氧化还原状态并氧化触发细胞凋亡。它还可能抑制大鼠乳腺肿瘤的形成。
硒-（甲基）硒代半胱氨酸是一种化学预防剂，可阻断癌前期乳腺病变的细胞周期进程和增殖，并诱导培养的癌细胞系凋亡。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Junkun Ma et al.
Biological trace element research, 191(1), 159-166 (2018-12-14)
Mastitis is one of the most important diseases affecting the dairy industry in the world, and it also poses a great threat to human food safety. In this study, we explored whether selenium can inhibit the activation of the NALP3
Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms.
N V Dolgova et al.
Metallomics : integrated biometal science, 8(3), 305-312 (2016-01-20)
Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been conflicting reports upon human health benefits and detriments arising
Dimethyldiselenide and methylseleninic acid generate superoxide in an in vitro chemiluminescence assay in the presence of glutathione: implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine.
Spallholz JE
Nutrition and Cancer, 40(1), 34-41 (2001)
Synchrotron-based X-ray absorption near-edge spectroscopy imaging for laterally resolved speciation of selenium in fresh roots and leaves of wheat and rice.
Wang P
Journal of Experimental Botany, 66(15), 4795-4806 (2015)
Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase.
Ellis DR
BMC plant biology, 4:1 (2004)
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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