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Merck
CN

M6690

Sigma-Aldrich

MDL 28170

≥90% (TLC), calpain I and II inhibitor

别名:

钙蛋白酶抑制剂 III

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关于此项目

经验公式（希尔记法）:
C22H26N2O4
化学文摘社编号:
88191-84-8
分子量:
382.45
MDL编号:
MFCD00798796
UNSPSC代码:
12352200
PubChem化学物质编号:
24278565
NACRES:
NA.77

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产品名称

MDL 28170, ≥90% (TLC)

质量水平

200

方案

≥90% (TLC)

组成

Peptide Content, >90%

溶解性

DMSO: 26 mg/mL
H2O: insoluble
methanol: soluble

运输

wet ice

储存温度

2-8°C

SMILES字符串

[H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C

InChI

1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1

InChI key

NGBKFLTYGSREKK-ANYOKISRSA-N

基因信息

human ... CAPN1(823), CAPN2(824)

相关类别

Amino Acid Sequence

Z-Val-Phe-al

应用

MDL 28170已被用作钙蛋白酶抑制剂：
  • 在大鼠心脏骤停模型中研究对神经炎症和坏死的影响
  • 分析对牛肉半膜肌神经元一氧化氮合酶(nNOS)降解的影响
  • 研究对大鼠脑损伤的保护作用及骨髓间充质干细胞在大鼠脑内的存活率

生化/生理作用

MDL 28170 是一种有效的细胞渗透性钙蛋白酶 I 和 II 抑制剂；减少培养的背根神经节神经元中辣椒素介导的细胞死亡。减少 H2O2 和 A23187 处理的 PC12 细胞凋亡的发生。γ-分泌酶抑制剂。
MDL 28170对大鼠脊髓损伤、局灶性脑缺血和新生儿缺氧缺血均有神经保护作用。它还有抗炎和抗神经退化特性。MDL 28170可穿过血脑屏障，并轻松穿透细胞膜。
有效的细胞渗透性钙蛋白酶 I 和 II 抑制剂；减少培养的背根神经节神经元中辣椒素介导的细胞死亡。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN7636
BCCL8337
BCCK4707
BCCH1187
BCCF4734

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Wen-Yan Wang et al.
International immunopharmacology, 93, 107377-107377 (2021-02-01)
Cerebral ischemia-reperfusion injury (CIRI) is the leading cause of poor neurological prognosis after cardiopulmonary resuscitation (CPR). We previously reported that the extracellular signal-regulated kinase (ERK) activation mediates CIRI. Here, we explored the potential ERK/calpain-2 pathway role in CIRI using a
Lorelei B Silverman-Gavrila et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(5), 1975-1990 (2013-02-01)
Low-frequency depression (LFD) of transmitter release occurs at phasic synapses with stimulation at 0.2 Hz in both isolated crayfish (Procambarus clarkii) neuromuscular junction (NMJ) preparations and in intact animals. LFD is regulated by presynaptic activity of the Ca(2+)-dependent phosphatase calcineurin
Jiangnan Hu et al.
Stem cell research & therapy, 10(1), 96-96 (2019-03-17)
Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number of transplanted BMSCs remains a pertinent challenge and can be attributed to the unfavorable microenvironment of the injured brain.
Stephanie N Thompson et al.
Journal of neurotrauma, 27(12), 2233-2243 (2010-09-30)
The cytoskeletal and neuronal protective effects of early treatment with the blood-brain barrier- and cell-permeable calpain inhibitor MDL-28170 was examined in the controlled cortical impact (CCI) traumatic brain injury (TBI) model in male CF-1 mice. This was preceded by a
Amy L Clark et al.
Scientific reports, 7(1), 5611-5611 (2017-07-19)
Pro-inflammatory cytokines are important mediators of islet inflammation, leading to beta cell death in type 1 diabetes. Although alterations in both endoplasmic reticulum (ER) and cytosolic free calcium levels are known to play a role in cytokine-mediated beta cell death
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