M6751
5-甲基胞嘧啶 盐酸盐
≥99%, synthetic (organic), crystalline powder
别名:
4-氨基-2-羟基-5-甲基嘧啶
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关于此项目
经验公式（希尔记法）:
C5H7N3O · HCl
化学文摘社编号:
分子量:
161.59
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
261-223-9
MDL number:
产品名称
5-甲基胞嘧啶 盐酸盐, ≥99%
InChI key
ANWMULVRPAUPJT-UHFFFAOYSA-N
InChI
1S/C5H7N3O.ClH/c1-3-2-7-5(9)8-4(3)6;/h2H,1H3,(H3,6,7,8,9);1H
SMILES string
O=C1NC(N)=C(C)C=N1.[H]Cl
biological source
synthetic (organic)
assay
≥99%
form
crystalline powder
solubility
water: 50 mg/mL, clear to slightly hazy, colorless
Quality Level
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Application
5-甲基胞嘧啶盐酸盐已被用作高效液相色谱（HPLC）法估计整体甲基化率的标准品。它还被用于高分辨率质谱分析。
5-甲基胞嘧啶被用于DNA甲基化过程（表观遗传学）的研究。
Biochem/physiol Actions
5-甲基胞嘧啶可介导基因表达、基因组印记和转位因子的抑制。它与翻译保真度和tRNA识别密切相关。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Ito S, et al.
Science (New York, N.Y.), 333(6047), 1300-1303 (2011)
Absolute quantification of RNA or DNA using acid hydrolysis and mass spectrometry
Lowenthal MS, et al.
Analytical Chemistry, 6, 824-824 (2019)
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
Squires JE, et al.
Nucleic Acids Research, 40(11), 5023-5033 (2012)
Rachel Deplus et al.
The EMBO journal, 32(5), 645-655 (2013-01-29)
TET proteins convert 5-methylcytosine to 5-hydroxymethylcytosine, an emerging dynamic epigenetic state of DNA that can influence transcription. Evidence has linked TET1 function to epigenetic repression complexes, yet mechanistic information, especially for the TET2 and TET3 proteins, remains limited. Here, we
Lan Jiang et al.
Cell, 153(4), 773-784 (2013-05-15)
5-methylcytosine is a major epigenetic modification that is sometimes called "the fifth nucleotide." However, our knowledge of how offspring inherit the DNA methylome from parents is limited. We generated nine single-base resolution DNA methylomes, including zebrafish gametes and early embryos.
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