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M6875

2-Mercaptopurine

Name: 2-Mercaptopurine
Brand: SIGMA

≥95%, crystalline

别名:

2-MP, 2-Purinethiol, 2-Thiopurine

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关于此项目

经验公式（希尔记法）:

C₅H₄N₄S

化学文摘社编号:

28128-19-0

分子量:

152.18

NACRES:

NA.51

PubChem Substance ID:

24897120

UNSPSC Code:

41106305

EC Number:

248-855-0

MDL number:

MFCD00047145

Assay:

≥95%

Form:

crystalline

Solubility:

1 M NH4OH: 50 mg/mL, clear to slightly hazy, yellow to brown

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属性

Quality Level

100

assay

≥95%

form

crystalline

color

yellow

solubility

1 M NH4OH: 50 mg/mL, clear to slightly hazy, yellow to brown

SMILES string

[H]n1cnc2cnc(S)nc12

InChI

1S/C5H4N4S/c10-5-6-1-3-4(9-5)8-2-7-3/h1-2H,(H2,6,7,8,9,10)

InChI key

HDBQZGJWHMCXIL-UHFFFAOYSA-N

说明

Application

2-Mercaptopurine (2-MP), a thiopurine and analog of the anti-cancer drug 6-mercaptopurine (6-MP), has been used to study the substrate and binding specificity and kinetics of xanthine oxidase-catalyzed hydroxylation and myeloperoxidase (MPO) reactions. 2-Mercaptopurine inhibited lipopolysacharide (LPS)-dependent nitric oxide (NO) production in B cells.

pictograms

GHS05,GHS07

signalword

Danger

hcodes

H302,H318

pcodes

P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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Simultaneous determination of glycol ethers and their acetates in cosmetics by gas chromatography with mass spectrometry.

Jinfeng Huang et al.

Journal of separation science, 41(11), 2354-2359 (2018-03-15)

A gas chromatography with mass spectrometry method was developed for the simultaneous determination of ten kinds of glycol ethers and their acetates in cosmetics. The samples were extracted with methanol/ethyl acetate (80:20, v/v), further treated with vortex and ultrasound, and

6-Mercaptopurine decreases the Bcl-2/Bax ratio and induces apoptosis in activated splenic B lymphocytes.

S Hortelano et al.

Molecular pharmacology, 51(3), 414-421 (1997-03-01)

6-Mercaptopurine and related purine antimetabolites are used in the treatment of several B cell disorders. These drugs inhibited the proliferation of mature splenic B cells after being triggered with polyclonal mitogens. In addition to the antiproliferative effects, 6-mercaptopurine, 2-mercaptopurine, and

Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase--enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different.

Hemlata Tamta et al.

Biochemistry. Biokhimiia, 72(2), 170-177 (2007-03-21)

Xanthine oxidase-catalyzed hydroxylation reactions of the anticancer drug 6-mercaptopurine (6-MP) and its analog 2-mercaptopurine (2-MP) as well as 6-thioxanthine (6-TX) and 2-thioxanthine (2-TX) have been studied using UV-spectroscopy, high pressure liquid chromatography, photodiode array, and liquid chromatography-based mass spectral analysis.

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全球贸易项目编号

货号	GTIN
M6875-25MG	04061833049716
M6875-100MG	04061833049709