M6875
2-Mercaptopurine
≥95%, crystalline
别名:
2-MP, 2-Purinethiol, 2-Thiopurine
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关于此项目
经验公式（希尔记法）:
C5H4N4S
化学文摘社编号:
分子量:
152.18
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
248-855-0
MDL number:
产品名称
2-Mercaptopurine, ≥95%, crystalline
InChI key
HDBQZGJWHMCXIL-UHFFFAOYSA-N
InChI
1S/C5H4N4S/c10-5-6-1-3-4(9-5)8-2-7-3/h1-2H,(H2,6,7,8,9,10)
SMILES string
[H]n1cnc2cnc(S)nc12
assay
≥95%
form
crystalline
color
yellow
solubility
1 M NH4OH: 50 mg/mL, clear to slightly hazy, yellow to brown
Quality Level
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Application
2-Mercaptopurine (2-MP), a thiopurine and analog of the anti-cancer drug 6-mercaptopurine (6-MP), has been used to study the substrate and binding specificity and kinetics of xanthine oxidase-catalyzed hydroxylation and myeloperoxidase (MPO) reactions. 2-Mercaptopurine inhibited lipopolysacharide (LPS)-dependent nitric oxide (NO) production in B cells.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Xi Chen et al.
Protein & cell, 10(5), 327-346 (2018-08-22)
Primitive mammalian heart transforms from a single tube to a four-chambered muscular organ during a short developmental window. We found that knocking out global microRNA by deleting Dgcr8 microprocessor in Mesp1 cardiovascular progenitor cells lead to the formation of extremely
Jinfeng Huang et al.
Journal of separation science, 41(11), 2354-2359 (2018-03-15)
A gas chromatography with mass spectrometry method was developed for the simultaneous determination of ten kinds of glycol ethers and their acetates in cosmetics. The samples were extracted with methanol/ethyl acetate (80:20, v/v), further treated with vortex and ultrasound, and
S Hortelano et al.
Molecular pharmacology, 51(3), 414-421 (1997-03-01)
6-Mercaptopurine and related purine antimetabolites are used in the treatment of several B cell disorders. These drugs inhibited the proliferation of mature splenic B cells after being triggered with polyclonal mitogens. In addition to the antiproliferative effects, 6-mercaptopurine, 2-mercaptopurine, and
Hemlata Tamta et al.
Biochemistry. Biokhimiia, 72(2), 170-177 (2007-03-21)
Xanthine oxidase-catalyzed hydroxylation reactions of the anticancer drug 6-mercaptopurine (6-MP) and its analog 2-mercaptopurine (2-MP) as well as 6-thioxanthine (6-TX) and 2-thioxanthine (2-TX) have been studied using UV-spectroscopy, high pressure liquid chromatography, photodiode array, and liquid chromatography-based mass spectral analysis.
The Effect of Swimming on Anxiety-Like Behaviors and Corticosterone in Stressed and Unstressed Rats.
Mohammad Amin Safari et al.
International journal of environmental research and public health, 17(18) (2020-09-18)
This study assessed the effect of swimming training on anxiety-like behaviors and corticosterone. Thirty adult male Wistar rats were randomly assigned to five study conditions: swimming training (ST); exposure to chronic mild stress (CS); exposure to chronic mild stress followed
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