M7033
NG-甲基-L-精氨酸 乙酸盐
≥98% (TLC), powder, nitric oxide synthase inhibitor
别名:
Nω-甲基-L-精氨酸 乙酸盐, L-NMMA, N5-（甲基脒基）-L-鸟氨酸 乙酸盐, NG-一甲基-L-精氨酸 乙酸盐
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关于此项目
经验公式（希尔记法）:
C7H16N4O2 · C2H4O2
化学文摘社编号:
分子量:
248.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
6674255
产品名称
NG-甲基-L-精氨酸 乙酸盐, ≥98% (TLC)
InChI key
IKPNWIGTWUZCKM-JEDNCBNOSA-N
SMILES string
CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O
InChI
1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
assay
≥98% (TLC)
form
powder
solubility
water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS3(4846)
mouse ... Nos2(18126)
rat ... Nos1(24598), Nos2(24599)
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Application
NG-甲基-L-乙酸精氨酸盐用于：
- 在受伤小鼠的伤口愈合研究中用作一氧化氮合酶（NOS）抑制剂
- 作为一氧化氮合酶（NOS）的抑制剂来研究小鼠干细胞的一氧化氮（NO）免疫抑制作用
- 作为抑制剂用于监测血细胞呼吸爆发测定中的NO水平
Biochem/physiol Actions
NG-甲基-L-精氨酸是神经元、内皮细胞和巨噬细胞中一氧化氮合酶的一种抑制剂。它可抑制内皮衍生的松弛因子并促进肺动脉和静脉的收缩。它能够立体选择性地抑制从精氨酸产生一氧化氮（NO）。它可促进肾上腺素和葡萄糖水平，从而导致中枢神经系统的高血糖症。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Nitric oxide induces epidermal stem cell de-adhesion by targeting integrin beta1 and Talin via the cGMP signalling pathway
Zhan R, et al.
Nitric Oxide, 78, 1-10 (2018)
Immune parameters in the common octopus (Octopus vulgaris Cuvier, 1797) naturally infected by the gastrointestinal protozoan parasite Aggregata octopiana
Castellanos-Martinez S and Gestal C
Aquaculture (Amsterdam, Netherlands), 497, 487-493 (2018)
NG-methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase
Olken NM and Marletta MA
Biochemistry, 32(37), 9677-9685 (1993)
NG-methyl-L-arginine, an inhibitor of nitric oxide synthase, affects the central nervous system to produce peripheral hyperglycemia in conscious rats
Uemura K, et al.
Neuroendocrinology, 66(2), 136-144 (1997)
NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein.
Gold ME, et al.
Proceedings of the National Academy of Sciences of the USA, 87(12), 4430-4434 (1990)
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