M7317
单克隆抗-MDR3 P-糖蛋白 小鼠抗
250 μg/mL, clone P3II-26, tissue culture supernatant
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关于此项目
Conjugate:
unconjugated
Clone:
P3II-26, monoclonal
Application:
ICC, IHC (f), IHC (p), WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
P3II-26, monoclonal
species reactivity
human
concentration
250 μg/mL
technique(s)
immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (not suitable for human tissues), immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections, western blot: suitable
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ABCB11(8647), ABCB4(5244)
General description
多药耐药蛋白3（MDR3）又称ATP结合盒亚家族B成员4。在肝细胞中表达，由1279个氨基酸组成。编码它的基因位于人类染色体7q21.12上，由27个外显子组成。
Immunogen
MDR3 P-gp（氨基酸629-692）GST融合蛋白。
Biochem/physiol Actions
与MDR3的内部表位反应。不与人MDR1 P-gp发生交叉反应。
多药耐药性蛋白3（MDR3）充当ATP依赖性输出物，并将磷脂，特别是磷脂酰胆碱（PC）转移到胆汁中。MDR3的功能障碍导致原发性胆汁中胆汁盐的过量，并进一步导致肝脏疾病。
Physical form
在含有0.7%牛血清白蛋白和0.1%叠氮化钠的无血清培养基中提供。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Marianne Kluth et al.
The Journal of biological chemistry, 290(8), 4896-4907 (2014-12-24)
The human multidrug resistance protein 3 (MDR3/ABCB4) belongs to the ubiquitous family of ATP-binding cassette (ABC) transporters and is located in the canalicular membrane of hepatocytes. There it flops the phospholipids of the phosphatidylcholine (PC) family from the inner to
Hao-Zhe Sun et al.
World journal of gastroenterology, 21(2), 699-703 (2015-01-17)
Genotyping is conclusive for the diagnosis of progressive familial intrahepatic cholestasis type 3 (PFIC3). Here we report a Chinese patient of PFIC3 with compound mutations in the ABCB4 gene. Liver biopsy was performed on a 17-year-old male patient with intrahepatic
Steffen Kiehl et al.
Scientific reports, 4, 6899-6899 (2014-11-05)
Epigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a novel epigenetically silenced target gene. We investigated the epigenetic regulation
Yu Zhao et al.
Journal of lipid research, 56(3), 644-652 (2015-01-21)
ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we
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