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安全信息

M7566

Sigma-Aldrich

Monoamine Oxidase Insect Cell Control

recombinant, expressed in wild-type baculovirus infected BTI insect cells

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别名:
MAO negative control
MDL编号:
MFCD08705570
NACRES:
NA.54

重组

expressed in wild-type baculovirus infected BTI insect cells

质量水平

200

形式

liquid

包装

vial of ~2.5 mg

运输

dry ice

储存温度

−70°C

一般描述

Monoamine oxidase is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs.

应用

Monoamine Oxidase inhibitors (MAOIs) are used to treat mental disorders including depression and Parkinson′s.
This product is suitable as a negative control for MAO-A and MAO-B.

生化/生理作用

Monoamine Oxidase (MAO) is an integral flavoprotein of the outer mitochondrial membrane. MAOs are responsible for catalyzing the oxidative deamination of a wide variety of xenobiotic and endobiotic primary, secondary, and tertiary amines. The primary endogenous function of MAOs involves the inactivation of monoamine neurotransmitters, such as serotonin and dopamine. MAOs exist in two isoforms, MAO-A and MAO-B, which share approximately 70% sequence identity on the amino acid level.1 Both isoforms are nearly ubiquitous in mammals, but show particularly high enzymatic activity in the central nervous system and liver.

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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Molly Wimbiscus et al.
Cleveland Clinic journal of medicine, 77(12), 859-882 (2010-12-15)
Monoamine oxidase (MAO) inhibitors were the first antidepressants introduced, but their use has dwindled because of their reported side effects, their food and drug interactions, and the introduction of other classes of agents. However, interest in MAO inhibitors is reviving.
Justin P Wright et al.
European journal of nuclear medicine and molecular imaging, 49(11), 3797-3808 (2022-05-22)
[18F]-labeled positron emission tomography (PET) radioligands permit in vivo assessment of Alzheimer's disease biomarkers, including aggregated neurofibrillary tau (NFT) with [18F]flortaucipir. Due to structural similarities of flortaucipir with some monoamine oxidase A (MAO-A) inhibitors, this study aimed to evaluate flortaucipir
Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors.
A S Kalgutkar et al.
Chemical research in toxicology, 14(9), 1139-1162 (2001-09-18)
M S Benedetti
Fundamental & clinical pharmacology, 15(2), 75-84 (2001-07-27)
Although the cytochrome P450 (CYP) system ranks first in terms of catalytic versatility and the wide range of xenobiotics it detoxifies or activates to reactive intermediates, the contribution of amine oxidases and in particular of monoamine oxidases (MAOs) to the
M B Youdim et al.
Biochemical pharmacology, 41(2), 155-162 (1991-01-15)
Identification, cellular localization, and cDNA cloning of MAO subtypes A and B have increased the insight into the pharmacology of these enzymes, whose primary functions are intra- and extraneuronal inactivation of neurotransmitter (dopamine, noradrenaline and serotonin) and other biogenic amines.

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