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M7694

莫匹罗星

Name: 莫匹罗星
Brand: SIGMA

920 – 1020 μg/mg (HPLC), crystalline

别名:

5,9-Anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-[2E,8[2S,3S(1S,2S)]]-L-talonon-2-enonic acid 8-carboxyoctyl ester, BRL 4910A, Pseudomonic acid

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关于此项目

经验公式（希尔记法）:

C₂₆H₄₄O₉

化学文摘社编号:

12650-69-0

分子量:

500.62

UNSPSC Code:

12352200

PubChem Substance ID:

24724542

NACRES:

NA.77

MDL number:

MFCD01711620

Assay:

920-1020 μg/mg (HPLC)

Form:

crystalline

Quality level:

100

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产品名称

莫匹罗星, 920-1020 μg/mg (HPLC), crystalline

Quality Level

100

assay

920-1020 μg/mg (HPLC)

form

crystalline

color

white to yellow

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits, protein synthesis | interferes

originator

GlaxoSmithKline

storage temp.

room temp

SMILES string

[H][C@@]1(CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)[C@H](O)[C@@H]1O)C[C@@H]2O[C@@]2([H])[C@@H](C)[C@H](C)O

InChI

1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1

InChI key

MINDHVHHQZYEEK-HBBNESRFSA-N

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General description

Mupirocin is produced by Pseudomonas fluorescens. Mupirocin is used to treat impetigo and skin infections.

Application

Mupirocin has been used:

for kinetic assay
to assess its resistance by performing turbidity assay
to determine its antimicrobial susceptibility

Biochem/physiol Actions

Antibiotic; inhibits isoleucyl-tRNA synthetase (IRS).

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Mupirocin is poorly soluble in water (26 mg/L), but highly soluble in DMSO (≥10 mg/mL). If sterilization is required, it is advisable to use filter sterilization with a 0.22 µm PTFE, Polypropylene, or Nylon filter membrane.

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Canine and Feline Dermatology Drug Handbook (2012)

Mupirocin: a topical antibiotic with a unique structure and mechanism of action.

Parenti MA, et al.

Clinical Pharmacy, 6(10), 761-770 (1987)

Complete nucleotide sequence and comparative analysis of pPR9, a 41.7-kilobase conjugative staphylococcal multiresistance plasmid conferring high-level mupirocin resistance.

Eduardo Pérez-Roth et al.

Antimicrobial agents and chemotherapy, 54(5), 2252-2257 (2010-03-10)

We have sequenced the conjugative plasmid pPR9, which carries the ileS2 gene, which had contributed to the dissemination of high-level mupirocin resistance at our institution. The plasmid backbone shows extensive genetic conservation with plasmids belonging to the pSK41/pGO1 family, but

Efficacy of topically delivered moxifloxacin against wound infection by Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus

Jacobsen F, et al.

Antimicrobial Agents and Chemotherapy, 55(5), 2325-2334 (2011)

Methods for detecting microbial methane production and consumption by gas chromatography

Aldridge JT, et al.

Bio-protocol, 6(7), 761-770 (2016)

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全球贸易项目编号

货号	GTIN
M7694-100MG	04061834062318
M7694-50MG	04061834062325

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