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Merck
CN

M7694

Sigma-Aldrich

莫匹罗星

≥92% (HPLC), isoleucyl-tRNA synthetase (IRS) inhibitor, powder

别名:

5,9-Anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-[2E,8[2S,3S(1S,2S)]]-L-talonon-2-enonic acid 8-carboxyoctyl ester, BRL 4910A, Pseudomonic acid

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关于此项目

经验公式（希尔记法）:
C26H44O9
化学文摘社编号:
12650-69-0
分子量:
500.62
MDL编号:
MFCD01711620
UNSPSC代码:
12352200
PubChem化学物质编号:
24724542
NACRES:
NA.77

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产品名称

莫匹罗星, 920-1020 μg/mg (HPLC), crystalline

方案

920-1020 μg/mg (HPLC)

表单

crystalline

颜色

white to yellow

抗生素抗菌谱

fungi

作用机制

enzyme | inhibits
protein synthesis | interferes

创始人

GlaxoSmithKline

储存温度

room temp

SMILES字符串

[H][C@@]1(CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)[C@H](O)[C@@H]1O)C[C@@H]2O[C@@]2([H])[C@@H](C)[C@H](C)O

InChI

1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1

InChI key

MINDHVHHQZYEEK-HBBNESRFSA-N

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相关类别

一般描述

Mupirocin is produced by Pseudomonas fluorescens. Mupirocin is used to treat impetigo and skin infections.

应用

Mupirocin has been used:
  • for kinetic assay
  • to assess its resistance by performing turbidity assay
  • to determine its antimicrobial susceptibility

生化/生理作用

Antibiotic; inhibits isoleucyl-tRNA synthetase (IRS).

特点和优势

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

制备说明

Mupirocin is poorly soluble in water (26 mg/L), but highly soluble in DMSO (≥10 mg/mL). If sterilization is required, it is advisable to use filter sterilization with a 0.22 µm PTFE, Polypropylene, or Nylon filter membrane.

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000126725
0000126724
0000126725
0000126724
0000167429

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Mupirocin: a topical antibiotic with a unique structure and mechanism of action.
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Clinical Pharmacy, 6(10), 761-770 (1987)
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