M7945
Mephetyl tetrazole
≥98% (HPLC), oil
别名:
1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole
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About This Item
经验公式（希尔记法）:
C20H22N4O
CAS Number:
分子量:
334.41
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
oil
颜色
pale yellow
溶解性
DMSO: >5 mg/mL
储存温度
2-8°C
SMILES字符串
COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1
InChI
1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3
InChI key
VREPWWBWXVLSEF-UHFFFAOYSA-N
生化/生理作用
Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker.
Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC50 = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.
特点和优势
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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