M7945
Mephetyl tetrazole
≥98% (HPLC), oil
别名:
1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole
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选择尺寸
关于此项目
经验公式（希尔记法）:
C20H22N4O
化学文摘社编号:
分子量:
334.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3
SMILES string
COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1
InChI key
VREPWWBWXVLSEF-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
oil
color
pale yellow
solubility
DMSO: >5 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker.
Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC50 = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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