Name: 丝裂霉素 C 来源于<I>头状链霉菌</I>
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₁₅H₁₈N₄O₅

CAS Number:

50-07-7

分子量:

334.33

Beilstein:

7231816

EC 号:

200-008-6

MDL编号:

MFCD00078109

UNSPSC代码:

51102829

PubChem化学物质编号:

329818045

NACRES:

NA.85

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生物来源

Streptomyces caespitosus

质量水平

200

无菌性

γ-irradiated

方案

≥98% (HPLC)

表单

powder or crystals

技术

cell culture | mammalian: suitable

颜色

dark blue

mp

>360 °C

溶解性

DMSO: 1.0 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
neoplastics

作用机制

DNA synthesis | interferes

储存温度

2-8°C

SMILES字符串

[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O

InChI

1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

InChI key

NWIBSHFKIJFRCO-WUDYKRTCSA-N

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应用

Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.

生化/生理作用

作用机制：该产物是专门针对鸟嘌呤核苷序列5′-CpG-3′的烷基化剂。它通过与DNA共价反应，在DNA互补链之间形成交联来抑制DNA合成。这种相互作用可防止DNA互补链分离，从而抑制DNA复制。

抗菌谱：丝裂霉素C具有很强的抗肿瘤活性，尤其是对艾氏腹水瘤细胞，对革兰氏阳性和革兰氏阴性细菌具有很强的杀菌作用。

注意

Stock solutions should be filter sterilized and stored at 2-8°C in the dark. Solutions at pH 6-9 can be stored at 0-5°C for up to a week, but if a precipitate forms, a fresh solution should be prepared - the precipitated solution has been proven toxic to cells.