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文件

安全信息

M8046

Sigma-Aldrich

米非司酮

≥98%

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别名:
11β-（4-二甲基-氨基）-苯基17β-羟基-17-（1-丙炔基）-雌甾-4,9-三胺-3-酮, RU-38486, RU-486
经验公式（希尔记法）:
C29H35NO2
CAS号:
84371-65-3
分子量:
429.59
MDL编号:
MFCD00867226
PubChem化学物质编号:
24278572
NACRES:
NA.77

生物来源

synthetic (organic)

无菌性

non-sterile

检测方案

≥98%

形式

powder

technique(s)

inhibition assay: suitable

溶解性

ethanol: 50 mg/mL, clear, greenish-yellow

创始人

Danco Laboratories

运输

ambient

储存温度

2-8°C

SMILES string

[H][C@@]12CCC3=CC(=O)CCC3=C1[C@H](C[C@@]4(C)[C@@]2([H])CC[C@@]4(O)C#CC)c5ccc(cc5)N(C)C

InChI

1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1

InChI key

VKHAHZOOUSRJNA-GCNJZUOMSA-N

Gene Information

human ... AR(367) , ESR1(2099) , ESR2(2100) , HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , NR3C1(2908) , NR3C2(4306) , PGR(5241)
mouse ... Nr3c1(14815)
rat ... Nr3c1(24413) , Tat(24813)

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应用

米非司酮用于：
  • 诱导破坏增殖和分泌期的子宫内膜基质细胞
  • 建立小鼠早产(PTB)模型，研究非早产和PTB宫颈成熟机制的差异
  • 激活果蝇基因开关gal4
  • 研究性类固醇对于前列腺素分泌的影响

生化/生理作用

因此，米非司酮被认为是一种强力的堕胎药。它还能抑制人绒毛膜促性腺激素。米非司酮导致蜕膜坏死。
米非司酮(RU-486)具有孕激素受体拮抗剂和糖皮质激素受体拮抗剂活性。

特点和优势

该化合物是受体分类及信号转导手册上核受体（类固醇）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
该化合物是由Danco实验室研发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360

预防措施声明

P201 - P308 + P313

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品

分析证书(COA)

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示例

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货号
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包装规格/数量

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  • 如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。

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索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is Mifepristone, Product M8046, soluble in?

    Mifepristone is soluble in ethanol at 50 mg/mL; heat may be required to dissolve the compound at this concentration.  It is also soluble in DMSO at 20 mg/mL.

  4. Can solutions of Mifepristone, Product M8046, be stored?

    Stock solutions of 1 mM mifepristone in ethanol can be stored at -20 °C. The top of the container should be sealed with Parafilm to prevent solvent evaporation. Solutions in ethanol, properly stored and handled, are probably good for several months (based on the structure of the compound), but we have no specific information on this.

  5. Where can I find information on usage of Mifepristone, Product M8046?

    The Sigma-Aldrich website listing has several cited articles with hyperlinks to the abstracts. These references can be found under the reference tab on the M8046 product webpage.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Meyler's Side Effects of Endocrine and Metabolic Drugs, 285-285 (2009)
Mesenchymal stem cells derived from Wharton jelly of the human umbilical cord ameliorate damage to human endometrial stromal cells
Yang X, et al.
Fertility and Sterility, 96(4), 1029-1036 (2011)
Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED
Park D, et al.
The Journal of Neuroscience, 34(39), 13195-13207 (2014)
The molecular mechanisms of cervical ripening differ between term and preterm birth
Holt R, et al.
Endocrinology, 152(3), 1036-1046 (2011)
Nynne Sharma et al.
Nucleic acids research, 36(11), e67-e67 (2008-05-24)
Nonviral integration systems are widely used genetic tools in transgenesis and play increasingly important roles in strategies for therapeutic gene transfer. Methods to efficiently regulate the activity of transposases and site-specific recombinases have important implications for their spatiotemporal regulation in
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