Monoclonal Anti-Mad1 antibody produced in mouse

Mitotic arrest deficient-like 1 (MAD1) is part of the cell-cycle checkpoint.

Monoclonal Anti-Mad1 (mouse IgG2b isotype) is derived from the hybridoma 9B10 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice immunized with human recombinant Mad1 protein.

recombinant human Mad1 protein.

Monoclonal Anti-Mad1 antibody produced in mouse has been used in

• immunoblotting
• immunoprecipitation
• immunocytochemistry

Mitotic arrest deficient-like 1 (MAD1) functions as a regulator in the segregation of chromosomes during mitosis. It recruits mitotic arrest deficient-like 2 (MAD2) to kinetochores and directs it to function as an inhibitor. MAD1 also helps MAD2 to associate with translocated promoter region (TPr).

Solution in 0.01 M phosphae buffered saline, pH 7.4, containing 15 mM sodium azide.

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