M8377
α-甲基- DL -色氨酸
≥98% (TLC), suitable for cell culture
别名:
α-methyl-tryptophan
Product Name
α-甲基- DL -色氨酸, crystalline
方案
≥98% (TLC)
质量水平
表单
crystalline
技术
tissue culture: suitable
颜色
light yellow
储存温度
2-8°C
SMILES字符串
CC(N)(Cc1c[nH]c2ccccc12)C(O)=O
InChI
1S/C12H14N2O2/c1-12(13,11(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,14H,6,13H2,1H3,(H,15,16)
InChI key
ZTTWHZHBPDYSQB-UHFFFAOYSA-N
应用
- 通过剥夺谷氨酰胺和级联血栓形成纳米工程声敏血小板协同增强声动力学肿瘤治疗: 该研究探索了使用α-甲基- DL -色氨酸，通过剥夺谷氨酰胺和诱发血栓形成来增进声动力学肿瘤治疗的效果，为癌症治疗提供了一条新途径（Zhou et al., 2023）。
- 靶向转运蛋白的加替沙星前药：合成、渗透性和眼睛局部给药: 该论文介绍了α-甲基- DL -色氨酸在靶向转运蛋白的前药开发中的应用， 改善了药物递送系统，特别是眼科治疗中的药物递送系统（Vooturi et al., 2012）。
- SLC6A14（ATB0,+）蛋白是一种高度集中的、具有广泛特异性的氨基酸转运蛋白，它是雌激素受体阳性乳腺癌治疗中有效的新型药物靶点。: 该研究考察了α-甲基- DL -色氨酸在雌激素受体阳性乳腺癌治疗中靶向 SLC6A14的作用，重点介绍了其成为治疗药的潜力（Karunakaran et al., 2011）。
生化/生理作用
α-甲基-DL-色氨酸是ATBo的阻滞剂，ATBo是一种氨基酸转运蛋白，其表达在癌症中上调。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Csaba Juhász et al.
Nuclear medicine and biology, 39(7), 926-932 (2012-03-27)
Tryptophan oxidation via the kynurenine pathway is an important mechanism of tumoral immunoresistance. Increased tryptophan metabolism via the serotonin pathway has been linked to malignant progression in breast cancer. In this study, we combined quantitative positron emission tomography (PET) with
Bálint Alkonyi et al.
Journal of neuro-oncology, 107(2), 365-372 (2011-11-04)
Dysembryoplastic neuroepithelial tumors (DNTs) are typically hypometabolic but can show increased amino acid uptake on positron emission tomography (PET). To better understand mechanisms of amino acid accumulation in epileptogenic DNTs, we combined quantitative α-[(11)C]methyl-L: -tryptophan (AMT) PET with tumor immunohistochemistry.
Sujatha Kannan et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 31(2), 738-749 (2010-09-10)
Maternal intrauterine inflammation is implicated in neurodevelopmental disorders in the offspring. Serotonin is crucial for regulating maturation in the developing brain, and maternal inflammation may result in disruption of the serotonergic system in the perinatal period. Saline or endotoxin was
Csaba Juhász et al.
Clinical nuclear medicine, 37(9), 838-842 (2012-08-15)
PET studies with α[C-11]methyl-L-tryptophan (AMT) have shown decreased serotonin synthesis based on a decrease of the unidirectional uptake rate (K-complex) in neuropsychiatric conditions such as autism and depression. Increased AMT K-complex in tumors can indicate increased tryptophan metabolism via the
Anita S D Saporta et al.
Journal of child neurology, 25(3), 336-342 (2009-09-15)
Previous studies in Tourette syndrome have reported lateralized abnormalities of neurotransmitters and microstructure of the cortico-striato-thalamo-cortical circuit. The authors analyzed the relationship between serotonin synthesis and microstructural changes in the subcortical structures (caudate nucleus, lentiform nucleus, and thalamus) related to
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