M8692
Anti-Matrix Metalloproteinase-21, Hinge Region antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-MMP-21
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
rat, human, Xenopus, mouse
technique(s)
western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MMP21(118856)
mouse ... Ighg(380794)
General description
Matrix metalloproteinase-21 (MMP-21) is a secreted protein expressed in fetal tissues, adult tissues and cancer cell lines. It is a 57kDa protein. The gene encoding it is localized on human chromosome 10.
Immunogen
synthetic peptide corresponding to the hinge region of human matrix metalloproteinase-21.
Biochem/physiol Actions
By immunoblotting against the reduced protein, the antibody identifies bands at 70 kDa and 66 kDa.
Matrix metalloproteinase-21 (MMP-21) is involved in increasing the invasion capacity and metastasis property of tumors.
Physical form
Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
法规信息
新产品
此项目有
Raja Ganesan et al.
PLoS pathogens, 13(2), e1006227-e1006227 (2017-02-14)
During intracellular infections, autophagy significantly contributes to the elimination of pathogens, regulation of pro-inflammatory signaling, secretion of immune mediators and in coordinating the adaptive immune system. Intracellular pathogens such as S. Typhimurium have evolved mechanisms to circumvent autophagy. However, the
Katja Ahokas et al.
Gene, 301(1-2), 31-41 (2002-12-20)
We have characterized a novel human matrix metalloproteinase (MMP-21) from human placenta DNA complementary to RNA (cDNA). The 569 amino acid translation of the cDNA includes all the typical features of an MMP family member, namely a signal sequence, a
Tao Wu et al.
Medical oncology (Northwood, London, England), 30(1), 323-323 (2013-01-01)
Matrix metalloproteinase-21 (MMP-21) has been shown to enhance tumor invasion and metastasis ability in some solid tumors. In the present study, we investigated the expression of MMP-21 as well as its association with overall survival of gastric cancer patients. MMP-21
Tiina Skoog et al.
Experimental dermatology, 15(10), 775-783 (2006-09-21)
Matrix metalloproteinase (MMP)-21 and MMP-26 (matrilysin-2) are two recently cloned epithelial metalloproteases. Here we examined their expression in various benign skin disorders, in which macrophages and fibroblasts have been implicated as well as in cultures of these cells. Expression of
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