Product Name
(R)-MG132,
方案
≥98%
质量水平
溶解性
DMSO or DMF: 25 mg/mL
储存温度
−20°C
SMILES字符串
CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O
InChI
1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
InChI key
TZYWCYJVHRLUCT-VABKMULXSA-N
应用
(R)-MG132已被用于泛素化测定并用作蛋白酶体抑制剂。
生化/生理作用
MG132(carbobenzoxy-Leu-Leu-leucinal)是一种三肽醛。它具有抗肿瘤活性，可增强化疗和放疗的细胞抑制/细胞毒性作用。(R)-MG132是一种有效的膜渗透性蛋白酶体抑制剂。它可以抑制J558L多发性骨髓瘤细胞和EMT6乳腺癌细胞裂解物中的蛋白酶体活性。与(S)-MG132相比，(R)-MG132立体异构体是更有效的胰凝乳蛋白酶样（ChTL）、胰蛋白酶样（TL）和肽酰谷氨酰肽水解蛋白酶体（PGPH）活性抑制剂。
外形
结晶固体或过冷液体
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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