M9131
2′-O-Monosuccinyladenosine 3′:5′-cyclic monophosphate
≥98%, synthetic (organic), powder
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关于此项目
经验公式（希尔记法）:
C14H16N5O9P
化学文摘社编号:
分子量:
429.28
EC 号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
产品名称
2′-O-Monosuccinyladenosine 3′:5′-cyclic monophosphate, ≥98%
生物来源
synthetic (organic)
方案
≥98%
表单
powder
溶解性
1 M NH4OH: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
(Nc1ncnc2c1ncn2C1OC2COP(=O)(O)OC2C1OC(=O)CCC(=O)O)
InChI
1S/C14H16N5O9P/c15-12-9-13(17-4-16-12)19(5-18-9)14-11(27-8(22)2-1-7(20)21)10-6(26-14)3-25-29(23,24)28-10/h4-6,10-11,14H,1-3H2,(H,20,21)(H,23,24)(H2,15,16,17)
InChI key
QNPSLGPIZRJDAN-UHFFFAOYSA-N
相关类别
应用
2′-O-Monosuccinyladenosine 3′:5′-cyclic monophosphate is a cAMP analog that may be used with other cAMP analogs to evaluate cAMP mediate processes within cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
S C Wen et al.
Endocrinology, 116(3), 935-944 (1985-03-01)
Adrenal cortical cells are known to export cAMP and have binding proteins and cAMP-dependent protein kinase activity associated with their plasma membranes. Because these properties suggest a function for extracellular cAMP, we have undertaken a search for specific cell surface
R A Richman et al.
Journal of cyclic nucleotide research, 6(6), 461-468 (1980-01-01)
Antisera to cyclic AMP and cyclic GMP were obtained by immunizing rabbits with antigens prepared by conjugating the 2'0-succinyl derivative of the cyclic nucleotides to thyroglobulin. The cyclic nucleotide-thyroglobulin conjugates were injected intradermally into multiple sites on the backs of
Michael Newton et al.
Analytical biochemistry, 402(2), 129-136 (2010-04-08)
Nitric oxide (NO) mediates intercellular signaling through activation of its receptor, soluble guanylyl cyclase (sGC), leading to elevation of intracellular guanosine 3',5'-cyclic monophosphate (cGMP) levels. Through this signal transduction pathway, NO regulates a diverse range of physiological effects, from vasodilatation
Vinay Bulusu et al.
Biochimica et biophysica acta, 1794(4), 642-654 (2008-12-30)
Adenylosuccinate lyase (ASL) catalyzes two distinct but chemically similar reactions in purine biosynthesis. The first, exclusive to the de novo pathway involves the cleavage of 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) to 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and fumarate and the second common to both
D Moreno-Delgado et al.
Neuroscience, 164(3), 1244-1251 (2009-09-09)
Histamine H(3) autoreceptors induce a negative feedback on histamine synthesis and release. While it is known that cAMP/cAMP dependent protein kinase (PKA) and Ca(2+)/CaMKII transduction pathways mediate H(3) effects on histamine synthesis, the pathways regulating neuronal histamine release are poorly
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