M9261
5-Methoxyuridine
别名:
mo(5)U
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关于此项目
经验公式（希尔记法）:
C10H14N2O7
化学文摘社编号:
分子量:
274.23
UNSPSC Code:
41106305
PubChem Substance ID:
EC Number:
252-609-8
MDL number:
InChI key
ZXIATBNUWJBBGT-JXOAFFINSA-N
InChI
1S/C10H14N2O7/c1-18-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)19-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1
SMILES string
COC1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(=O)NC1=O
assay
≥98% (HPLC), ≥99% (TLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
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Application
5-Methoxyuridine is a constituent of the first position of the anticodon of select bacterial tRNA molecules. 5-Methoxyuridine may be used to study the effects of substitutions on the codon reading efficiencies of tRNAs.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Rebuma Firdessa-Fite et al.
Molecular therapy. Methods & clinical development, 16, 50-62 (2019-12-25)
The efficacy of antigen-specific immunotherapy relies heavily on efficient antigen delivery to antigen-presenting cells and engagement of as many disease-relevant T cells as possible in various lymphoid tissues, which are challenging to achieve. Here, we compared two approaches to deliver mRNA
5-Methoxyuridine, a new modified constituent in tRNAs of Bacillaceae.
M Albani et al.
FEBS letters, 70(1), 37-42 (1976-11-01)
S Okumura et al.
Nucleic acids symposium series, 34(34), 203-204 (1995-01-01)
Effects of a single nucleoside modification at the first position of the anticodon of a transfer RNA molecule on its codon reading properties were investigated by use of a cell-free protein synthesis. We prepared two artificial tRNA molecules that differ
K Murao et al.
Nucleic acids research, 3(10), 2851-2860 (1976-10-01)
The sequences of the anticodon of tRNAAla, tRNAThr, and tRNAVal from Bacillus subtilis W 168 were N-G-C, N-G-U, and N-A-C, respectively. A new minor constituent, N, occupied the first position of the anticodon of each tRNA. N was indentified as
Yuko Yamada et al.
Biochimica et biophysica acta, 1728(3), 143-149 (2005-04-19)
In Bacillus subtilis, four codons, CCU, CCC, CCA, and CCG, are used for proline. There exists, however, only one proline-specific tRNA having the anticodon mo(5)UGG. Here, we found that this tRNA(Pro)(mo(5)UGG) can read not only the codons CCA, CCG and
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