产品名称
IgG1，κ 来源于鼠骨髓瘤, clone MOPC 21, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
MOPC 21, monoclonal
form
buffered aqueous solution
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
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相关类别
Application
IgG1, κ（来自鼠骨髓瘤）已用于：
- 球结膜切片的原位杂交实验
- 牛和动脉组织的免疫组化
IgG1，κ（来自小鼠骨髓瘤）已用于流式细胞分析和免疫沉淀技术。
IgG1, κ（来自小鼠骨髓瘤）已用于：
- 白细胞免疫荧光，50 μg/ml浓度
- 作为酶联免疫吸附测定(ELISA)的标准品
- 通过凝胶过滤和离心技术进行置换浓缩用于荧光标记
Biochem/physiol Actions
IgG1 分子量为 146 kDa，是一种大量表达的 IgG 亚类。IgG1 缺陷导致总 IgG 水平总体下降，从而导致低丙种球蛋白血症。IgG1 促进细菌吞噬作用，介导疫苗诱导的感染保护作用。IgG2a 与 IgG1 的比例对抗热带利什曼原虫感染的免疫应答至关重要。其与 Fcγ 受体 (FcγR) 具有高结合亲和力。高水平 IgG1-κ抗体与肾小球肾炎的病理有关。
IgG抗体亚型存在于血浆和细胞外液中，提供抗细菌、真菌和病毒的保护作用。母体IgG可通过胎盘转移至胎儿，胎盘对新生儿免疫防御感染至关重要。
特异性通过小鼠单克隆抗体分型试纸条测定。该纯化免疫球蛋白制品与小鼠IgA、IgM、IgG2a、IgG2b和IgG3都不具反应性。
Disclaimer
除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
Physical form
0.02 MTris 缓冲盐溶液，pH 8.0，含 0.02% 叠氮化钠
Preparation Note
−20 °C储存。本品可以工作等分试样的形式在-20 °C下冻存。不建议反复冻融。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Circulating monoclonal IgG1-kappa antibodies causing anti-glomerular basement membrane nephritis.
Vankalakunti M, et al.
Indian journal of nephrology, 27(4), 327-327 (2017)
G G de Sá Oliveira et al.
Clinical and experimental immunology, 105(2), 313-320 (1996-08-01)
The specificities of a panel of erythrocyte-reactive MoAbs derived from NZB mice with autoimmune haemolytic anaemia (AIHA) were determined by immunoprecipitation and immunoblotting. Of the eight antibodies, two (IgG1 MoAb 105-2H and IgG2a MoAb 34-3C) immunoprecipitated a 105-kD component identified
Phillip A Doerfler et al.
Clinical immunology (Orlando, Fla.), 158(2), 140-147 (2015-04-07)
Antibodies formed against the therapeutic protein are a life-threatening complication that arises during enzyme replacement therapy for Pompe disease (acid α-glucosidase deficiency; GAA). To provide an effective alternative to current practices, we investigated the capacity of anti-B-cell activating factor (BAFF)
Cecilia Lässer et al.
Journal of visualized experiments : JoVE, (59), e3037-e3037 (2012-01-20)
The field of exosome research is rapidly expanding, with a dramatic increase in publications in recent years. These small vesicles (30-100 nm) of endocytic origin were first proposed to function as a way for reticulocytes to eradicate the transferrin receptor
Elin Borgen et al.
Breast cancer research : BCR, 20(1), 120-120 (2018-10-17)
The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state over time, but clinical studies of
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