M9432
Anti-Macrophage Inflammatory Protein-2, Viral antibody produced in goat
affinity isolated antibody, lyophilized powder
别名:
Anti-MIP 2, Viral
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UNSPSC Code:
51111800
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
3
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
viral
technique(s)
indirect ELISA: 0.5-1.0 μg/mL, western blot: 0.1-0.2 μg/mL
storage temp.
−20°C
target post-translational modification
unmodified
General description
The genome of Kaposi′s sarcoma-associated herpes virus (KSHV) encodes two gene products that are similar to the sequence of human chemokine, MIP-1α. These are named according to the human protein counterpart as viral macrophage inflammatory protein (vMIP)-I and –II. The sequence identity of vMIP-I and vMIP-II to human MIP-1α is 37.9% and 41.1%, respectively. The expression of vMIP-1 and vMIP-2 are reportedly induced by phorbol esters in latently infected lymphoma cells. Both vMIP-I and vMIP-II partially inhibit the infection of peripheral blood mononuclear cells by HIV. vMIP-II also reportedly blocks the infection of CD4-positive cell line expressing CCR3 by HIV, type-1
Anti-Macrophage Inflammatory Protein-II (MIP-II) recognizes recombinant viral MIP-II. The antibody shows less than 10% cross reactivity with recombinant viral MIP-I and recombinant human MIP-1b.
Anti-Macrophage Inflammatory Protein-II (MIP-II) recognizes recombinant viral MIP-II. The antibody shows less than 10% cross reactivity with recombinant viral MIP-I and recombinant human MIP-1b.
Immunogen
recombinant viral MIP 2, expressed in E. coli.
Application
Anti-Macrophage Inflammatory Protein-II (MIP-II) antibody may be used in immunoblotting at a working concentration of 0.1-0.2 μg/ml. For ELISA the recommended concentration is 0.5-1.0 μg/ml.
Biochem/physiol Actions
The antibody will recognize recombinant viral MIP-2. The antibody shows <10% cross-reactivity with recombinant viral MIP-1 and recombinant human MIP-1β.
Physical form
Lyophilized from a 0.2 μm-filtered solution in phosphate-buffered saline.
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J J Russo et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(25), 14862-14867 (1996-12-10)
The genome of the Kaposi sarcoma-associated herpesvirus (KSHV or HHV8) was mapped with cosmid and phage genomic libraries from the BC-1 cell line. Its nucleotide sequence was determined except for a 3-kb region at the right end of the genome
P S Moore et al.
Science (New York, N.Y.), 274(5293), 1739-1744 (1996-12-06)
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected
C Boshoff et al.
Science (New York, N.Y.), 278(5336), 290-294 (1997-10-10)
Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser
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