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About This Item
经验公式（希尔记法）:
C7H8N2O3
CAS Number:
分子量:
168.15
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
>98% (HPLC)
表单
powder
颜色
red-brown
溶解性
DMSO: soluble 18 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
CN(N=O)c1ccc(O)c(O)c1
InChI
1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3
InChI key
XAKAQCMEMMZUEO-UHFFFAOYSA-N
基因信息
human ... PTPN1(5770)
应用
Methyl-3,4-dephostatin has been used as:
- an inhibitor for methyltransferases
- a kinase-related inhibitor for human transglutaminase
- a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein
生化/生理作用
Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).
Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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