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M9440

Methyl-3,4-dephostatin

Name: Methyl-3,4-dephostatin
Brand: SIGMA

>98% (HPLC), powder

别名:

3,4-Dihydroxy-N-methyl-N-nitrosoaniline

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关于此项目

经验公式（希尔记法）:

C₇H₈N₂O₃

化学文摘社编号:

173043-84-0

分子量:

168.15

NACRES:

NA.77

PubChem Substance ID:

24278575

UNSPSC Code:

12352200

MDL number:

MFCD01076450

Assay:

>98% (HPLC)

Form:

powder

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属性

Quality Segment

100

assay

>98% (HPLC)

form

powder

color

red-brown

solubility

DMSO: soluble 18 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

CN(N=O)c1ccc(O)c(O)c1

InChI

1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3

InChI key

XAKAQCMEMMZUEO-UHFFFAOYSA-N

Gene Information

human ... PTPN1(5770)

说明

Application

Methyl-3,4-dephostatin has been used as:

an inhibitor for methyltransferases
a kinase-related inhibitor for human transglutaminase
a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein

Biochem/physiol Actions

Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).

Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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