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Merck
CN

M9651

马普替林 盐酸盐

>99% (HPLC), powder

别名:

9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride

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经验公式(希尔记法):
C20H23N · HCl
化学文摘社编号:
分子量:
313.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
233-758-8
MDL number:
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InChI

1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H

InChI key

NZDMFGKECODQRY-UHFFFAOYSA-N

SMILES string

Cl.CNCCCC12CCC(c3ccccc13)c4ccccc24

assay

>99% (HPLC)

form

powder

color

white

solubility

H2O: 50 mg/mL

originator

Novartis

Quality Level

Gene Information

human ... SLC6A2(6530)

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Application

Maprotiline hydrochloride has been used as a inhibitor of norepinephrine uptake to study its effects on arresting L3055 cell proliferation.

Biochem/physiol Actions

Maprotiline is a tetracyclic agent. It possesses inhibitory effects against the uptake of norepinephrine by nerve cells. Maprotiline exhibits anti-depressant and sedative activity.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Chemistry, pharmacology, pharmacokinetics, adverse effects, and efficacy of the antidepressant maprotiline hydrochloride
Wells B G and Gelenberg A J
Pharmacotherapy, 1(2), 121-138 (1981)
E Hösli et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 13(8), 897-908 (1995-12-01)
Autoradiographic studies were made on the uptake of 3H-noradrenaline and 3H-serotonin in explant cultures and primary astrocyte cultures from various regions of rat central nervous system (cortex, cerebellum, locus coeruleus, nucleus raphé, spinal cord). In explant cultures from locus coeruleus
The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential antitumor target for psychotropics
Meredith E J, et al.
Faseb Journal, 19(9), 1187-1189 (2005)
C C Beaufour et al.
Pharmacology, biochemistry, and behavior, 62(4), 591-599 (1999-04-20)
The effects of chronic antidepressants were investigated in an animal procedure for the study of anxiety and anxiolytics, the conditioned suppression of operant behavior in rats. In daily 18-min sessions, three periods of nonpunished lever pressing for food alternated with
Edward C Lauterbach et al.
The Journal of neuropsychiatry and clinical neurosciences, 22(1), 8-18 (2010-02-18)
This manuscript reviews the preclinical in vitro, ex vivo, and nonhuman in vivo effects of psychopharmacological agents in clinical use on cell physiology with a view toward identifying agents with neuroprotective properties in neurodegenerative disease. These agents are routinely used

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