M9771
N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin
elastase substrate
别名:
MeOSuc-AAPV-AMC
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关于此项目
经验公式（希尔记法）:
C31H41N5O9
化学文摘社编号:
分子量:
627.69
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
产品名称
N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin, elastase substrate
InChI
1S/C31H41N5O9/c1-16(2)27(30(42)34-20-9-10-21-17(3)14-26(39)45-23(21)15-20)35-29(41)22-8-7-13-36(22)31(43)19(5)33-28(40)18(4)32-24(37)11-12-25(38)44-6/h9-10,14-16,18-19,22,27H,7-8,11-13H2,1-6H3,(H,32,37)(H,33,40)(H,34,42)(H,35,41)
SMILES string
COC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI key
CMEUDEVBFFPSEI-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
solubility
chloroform: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
Application
N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin has been used as a substrate in elastase assay using bone marrow lysates and pancreatic lysates.
General description
Fluorogenic substrate for the assay of human leukocyte and porcine pancreatic elastase.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jonas Hahn et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1401-1414 (2018-08-22)
Papillon-Lefèvre syndrome (PLS) is characterized by nonfunctional neutrophil serine proteases (NSPs) and fulminant periodontal inflammation of unknown cause. Here we investigated neutrophil extracellular trap (NET)-associated aggregation and cytokine/chemokine-release/degradation by normal and NSP-deficient human and mouse granulocytes. Stimulated with solid or
Gerrit Wolters-Eisfeld et al.
Experimental & molecular medicine, 50(10), 1-13 (2018-10-12)
Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. Thus, it plays a crucial role in the biosynthesis of O-linked glycosylation of proteins. Here, we show that ablation of
Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases.
M J Castillo et al.
Analytical biochemistry, 99(1), 53-64 (1979-10-15)
Teresa I Ng et al.
Antimicrobial agents and chemotherapy, 62(1) (2017-11-01)
Glecaprevir (formerly ABT-493) is a novel hepatitis C virus (HCV) NS3/4A protease inhibitor (PI) with pangenotypic activity. It inhibited the enzymatic activity of purified NS3/4A proteases from HCV genotypes 1 to 6 in vitro (half-maximal [50%] inhibitory concentration = 3.5
D Polacek et al.
The Journal of biological chemistry, 261(5), 2057-2063 (1986-02-15)
In vitro incubation of human plasma low density lipoproteins (LDL) with human blood polymorphonuclear cells (PMN) for 1 h at 37 degrees C resulted in an increased (2-4-fold) release into the medium of an enzymatic activity which co-eluted with LDL
商品
Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.
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