产品名称
支链氨基酸试剂盒, sufficient for 100 colorimetric tests
usage
sufficient for 100 colorimetric tests
detection method
colorimetric
relevant disease(s)
endocrinological disorders, diabetes; gastrointestinal diseases; neurological disorders
storage temp.
−20°C
Application
在一项评估 CREB 调节的转录辅激活因子 2 角色 （CRTC2）在小鼠肝脏脂质稳态和肥胖中的作用的研究中，支链氨基酸试剂盒已被用于测定肝脏支链氨基酸的浓度。
适用于测定多种生物样品中的支链氨基酸 (BCAA)。
Biochem/physiol Actions
在该试验中，使用偶联酶反应测定 BCAA 浓度，得到与存在的 BCAA 成比例的比色 (450 nm) 产物。BCAA 检测试剂盒为测定各种生物样本中的 BCAA 提供了一种简单方便的方法。
General description
支链氨基酸 (BCAA)、亮氨酸、异亮氨酸和缬氨酸是蛋白质中最常见的必需氨基酸。BCAA 可能在能量生产和营养信号中发挥作用。膳食补充 BCAA 可能有助于治疗各种疾病，如肌萎缩侧索硬化 (ALS)、隐匿性和慢性肝性脑病 ，并预防癌症患者的肌肉萎缩。BCAA 可增加蛋白质合成速率，使细胞对胰岛素和胰岛素样生长因子敏感。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
法规信息
常规特殊物品
此项目有
Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle.
Frost R A and Charles H L
Endocrinol. Metab. Clin., 41(2), 297-322 (2012)
Itziar Lamiquiz-Moneo et al.
Cells, 9(3) (2020-03-18)
The global prevalence of type 2 diabetes (T2D) is increasing rapidly, especially in low- and middle-income countries and has a high number of associated comorbidities. Plasmatic concentrations of branched chain amino acids (BCAA) and retinol-binding protein 4 (RBP4) have been
Hager M Kowash et al.
Clinical science (London, England : 1979), 136(15), 1117-1137 (2022-07-20)
Maternal infection during pregnancy increases the offspring risk of developing a variety of neurodevelopmental disorders (NDDs), including schizophrenia. While the mechanisms remain unclear, dysregulation of placental function is implicated. We hypothesised that maternal infection, leading to maternal immune activation and
Aidan M Sokolov et al.
Human molecular genetics, 29(18), 3003-3013 (2020-08-22)
Pathogenic mutations in the solute carrier family 7 member 5 (SLC7A5) gene, which encodes an amino acid transporter cause microcephaly and seizures, yet the mechanisms responsible for these phenotypes are unclear. Models have demonstrated that Slc7a5 deletion is embryonic lethal
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.
Han J, et al.
Nature, 524(7564), 243-243 (2015)
商品
Assay protocol for the colorimetric detection of Branched Chain Amino Acids (BCAA) in biological samples using the alanine assay kit.
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