usage
sufficient for 100 colorimetric or fluorometric tests
application(s)
cosmetics
food and beverages
detection method
colorimetric, fluorometric
relevant disease(s)
cancer
storage temp.
−20°C
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General description
柠檬酸是三羧酸（TCA）循环的关键中间体，通过向乙酰辅酶A的乙酰基中加入草酰乙酸而得。柠檬酸通过柠檬酸-苹果酸梭子从线粒体中转运出来，然后转化回乙酰辅酶A进行脂肪酸合成。柠檬酸是脂肪酸合成和糖酵解的别构调节剂，分别通过作用于乙酰辅酶A羧化酶和磷酸果糖激酶来实现。由于性别、年龄和各种其他因素（包括疾病状态），柠檬酸的代谢和分布差异可能很大。前列腺癌细胞中的细胞柠檬酸水平降低，柠檬酸水平可能是前列腺癌生长速率的标志物。柠檬酸检测试剂盒提供了一种可简单、灵敏、快速地对各种样品中的柠檬酸进行定量的方法。
Application
柠檬酸检测试剂盒用于检测样品中柠檬酸的浓度。
适用于对包括组织和细胞在内的多种样品中的柠檬酸盐进行测定
Biochem/physiol Actions
柠檬酸的浓度通过酶偶联法检测，产生与存在的柠檬酸成比例的比色（570 nm）/荧光（λex = 535/λem = 587 nm）产物。柠檬酸检测试剂盒的灵敏度在各种样品中通常为0.1至10 nM（2 μmM-10 mM）柠檬酸。
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
法规信息
监管及禁止进口产品
此项目有
Ricardo Villa-Bellosta et al.
Scientific reports, 9(1), 11374-11374 (2019-08-08)
Vascular calcification is highly prevalent in patients with chronic hemodialysis. Increased acetatemia during hemodialysis sessions using acetate-acidified bicarbonate has also been associated with several abnormalities, By contrast, these abnormalities were not induced by citrate-acidified bicarbonate dialysis. Moreover, citrate is biocompatible
Di Zhu et al.
Science advances, 6(31), eabb2529-eabb2529 (2020-08-14)
Mild mitochondrial stress experienced early in life can have beneficial effects on the life span of organisms through epigenetic regulations. Here, we report that acetyl-coenzyme A (CoA) represents a critical mitochondrial signal to regulate aging through the chromatin remodeling and
Nimrit Goraya et al.
Kidney international, 95(5), 1190-1196 (2019-03-09)
Acid (H+) retention appears to contribute to progressive decline in glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD), including some patients without metabolic acidosis. Identification of patients with H+ retention but without metabolic acidosis could facilitate targeted
Jade D Bailey et al.
Cell reports, 28(1), 218-230 (2019-07-04)
Classical activation of macrophages (M(LPS+IFNγ)) elicits the expression of inducible nitric oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial respiration. Upregulation of glycolysis and a disrupted tricarboxylic acid (TCA) cycle underpin this switch to a pro-inflammatory phenotype.
Cheng Zhang et al.
Cell reports, 21(8), 2058-2065 (2017-11-23)
We discovered that induced pluripotent stem cell (iPSC) clones generated from aged tissue donors (A-iPSCs) fail to suppress oxidative phosphorylation. Compared to embryonic stem cells (ESCs) and iPSCs generated from young donors (Y-iPSCs), A-iPSCs show poor expression of the pluripotent
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Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
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