产品名称
丙酮酸检测试剂盒, sufficient for 100 colorimetric or fluorometric tests
usage
sufficient for 100 colorimetric or fluorometric tests
detection method
colorimetric
fluorometric
relevant disease(s)
gastrointestinal diseases; cancer
storage temp.
−20°C
Gene Information
human ... PKLR(5313), PKM2(5315)
mouse ... PKLR(18770), PKM2(18746)
rat ... PKLR(24651), PKM2(25630)
Application
适于测定血液、组织、培养细胞等多种生物样品中的丙酮酸浓度。
Biochem/physiol Actions
由偶联酶测定法测定丙酮酸浓度，得到的比色（570nm）/荧光（λex = 535/λem =587 nm）产物与存在丙酮酸成比例。
General description
丙酮酸是代谢中的中心分子，其通过多种代谢途径进行使用和合成，其中包括糖酵解和丙氨酸的氨基转移作用。丙酮酸可在柠檬酸循环中进一步氧化，在糖异生期间转化为碳水化合物，或还原为乳酸。高水平的丙酮酸与肝脏疾病和遗传性疾病有关。丙酮酸也被用于刺激代谢，从而导致体重减轻。
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 3 - Resp. Sens. 1 - Skin Sens. 1
存储类别
10 - Combustible liquids
法规信息
常规特殊物品
此项目有
Lauren K Wareham et al.
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Changes in muscle cell metabolism and mechanotransduction are associated with myopathic phenotype in a mouse model of collagen VI deficiency.
De Palma S, et al.
PLoS ONE, 8(2), e56716-e56716 (2013)
Abstracts of the XVIth International Conference on Biological Inorganic Chemistry, July 22-26, 2013, Grenoble, France.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 19 Suppl 1, 1-696 (2014-03-13)
Claire G Jeong et al.
Acta biomaterialia, 10(8), 3421-3430 (2014-05-27)
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Natarajaseenivasan K, et al.
Cell Death & Disease, 9(4), 415-415 (2018)
商品
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
本页面介绍了一篇有关瓦博格效应的文章，以及其如何能够在正常氧气水平下，增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明，癌细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。
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