usage
sufficient for 100 colorimetric or fluorometric tests
detection method
colorimetric, fluorometric
relevant disease(s)
gastrointestinal diseases; cancer
storage temp.
−20°C
Gene Information
human ... PKLR(5313), PKM2(5315)
mouse ... PKLR(18770), PKM2(18746)
rat ... PKLR(24651), PKM2(25630)
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General description
丙酮酸是代谢中的中心分子，其通过多种代谢途径进行使用和合成，其中包括糖酵解和丙氨酸的氨基转移作用。丙酮酸可在柠檬酸循环中进一步氧化，在糖异生期间转化为碳水化合物，或还原为乳酸。高水平的丙酮酸与肝脏疾病和遗传性疾病有关。丙酮酸也被用于刺激代谢，从而导致体重减轻。
Application
适于测定血液、组织、培养细胞等多种生物样品中的丙酮酸浓度。
Biochem/physiol Actions
由偶联酶测定法测定丙酮酸浓度，得到的比色（570nm）/荧光（λex = 535/λem =587 nm）产物与存在丙酮酸成比例。
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 3 - Resp. Sens. 1 - Skin Sens. 1
存储类别
10 - Combustible liquids
法规信息
常规特殊物品
此项目有
Abstracts of the XVIth International Conference on Biological Inorganic Chemistry, July 22-26, 2013, Grenoble, France.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 19 Suppl 1, 1-696 (2014-03-13)
Changes in muscle cell metabolism and mechanotransduction are associated with myopathic phenotype in a mouse model of collagen VI deficiency.
De Palma S, et al.
PLoS ONE, 8(2), e56716-e56716 (2013)
Lauren K Wareham et al.
Antioxidants & redox signaling, 24(17), 1013-1028 (2016-02-26)
Carbon monoxide is a respiratory poison and gaseous signaling molecule. Although CO-releasing molecules (CORMs) deliver CO with temporal and spatial specificity in mammals, and are proven antimicrobial agents, we do not understand the modes of CO toxicity. Our aim was
Sara De Palma et al.
PloS one, 8(2), e56716-e56716 (2013-02-26)
This study identifies metabolic and protein phenotypic alterations in gastrocnemius, tibialis anterior and diaphragm muscles of Col6a1(-/-) mice, a model of human collagen VI myopathies. All three muscles of Col6a1(-/-) mice show some common changes in proteins involved in metabolism
Han Sun et al.
Communications biology, 3(1), 186-186 (2020-04-25)
Accumulation of high-value products in microalgae is not conducive with rapid cell growth, which is the potential conflict in microalgal production. Overcoming such conflict faces numerous challenges in comprehensively understanding cell behavior and metabolism. Here, we show a fully integrated interaction
商品
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
本页面介绍了一篇有关瓦博格效应的文章，以及其如何能够在正常氧气水平下，增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明，癌细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。
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