用途
sufficient for 100 colorimetric tests
检测方法
colorimetric
相关疾病
cardiovascular diseases; neurological disorders; cancer; gastrointestinal diseases
储存温度
−20°C
基因信息
human ... GGT1(2678), GGT2(728441), GGT5(2687), GGT6(124975), GGT7(2686)
mouse ... GGT1(14598), GGT5(23887), GGT6(71522), GGT7(207182)
rat ... GGT1(116568), GGT5(29566), GGT6(408206), GGT7(156275)
一般描述
γ-谷氨酰转移酶（GGT，EC 2.3.2.2）是膜结合蛋白，其催化谷氨酰基部分向受体分子（如氨基酸或肽）的转移。GGT在λ-氨酰循环中起关键作用，谷氨酰胺循环是谷胱甘肽稳态以及异生素解毒的关键途径。血清GGT水平可在许多病理生理条件下升高，例如心血管疾病、慢性肝病和代谢综合征。血清GGT水平升高也可以指示氧化应激。
应用
γ-谷氨酰转移酶（GGT）活性比色测定试剂盒已用于评估γ-谷氨酰转移酶的活性。
适用于多种样本（包括组织，细胞和血清）中γ-谷氨酰胺转移酶（GGT）的测定
生化/生理作用
GGT 活性比色测定试剂盒提供了一种简单、直接的方法，用于测量各种样品中的GGT 活性。通过偶联酶测定法测定 GGT 活性，其中GGT 从底物 L-γ-氨酰基-对硝基苯胺转移γ-谷氨酰基，释放与存在的GGT 成比例的色原体对硝基苯胺（pNA，418nm）。一个单位的GGT是在37°C下，每分钟产生 1.0μmole pNA的酶的量。
特点和优势
与高通量处理系统兼容。
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα.
Bauer R C, et al.
The Journal of Clinical Investigation, 125(10), 3809-3818 (2015)
Eslam E Abd El-Fattah et al.
Frontiers in pharmacology, 12, 720173-720173 (2022-02-01)
HIF-1α is a key factor promoting the development of hepatocellular carcinoma (HCC). As well, AKT-AMPKα-mTOR signaling is a promising target for cancer therapy. Yet, the AKT-AMPKα-mTOR-dependent activation of HIF-1α has not been studied in livers with HCC. In addition, the
Piyush Bajaj et al.
Drug metabolism and disposition: the biological fate of chemicals, 46(11), 1703-1711 (2018-09-02)
Current in vitro models for identifying nephrotoxins are poorly predictive. We differentiated human pluripotent stem cells (hPSCs) into three-dimensional, multicellular structures containing proximal tubule cells (PTCs) and podocytes and evaluated them as a platform for predicting nephrotoxicity. The PTCs showed
Anna Wądołek et al.
International journal of molecular sciences, 22(19) (2021-10-14)
One of the consequences of long-term exposure to air pollutants is increased mortality and deterioration of life parameters, especially among people diagnosed with cardiovascular diseases (CVD) or impaired respiratory system. Aqueous soluble inorganic components of airborne particulate matter containing redox-active
Floris J M Roos et al.
Frontiers in cell and developmental biology, 8, 630492-630492 (2021-02-27)
Diseases of the bile duct (cholangiopathies) remain a common indication for liver transplantation, while little progress has been made over the last decade in understanding the underlying pathophysiology. This is largely due to lack of proper in vitro model systems
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