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安全信息

MAK099

Sigma-Aldrich

谷氨酸脱氢酶(GDH)活性检测试剂盒

sufficient for 100 colorimetric tests

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用途

sufficient for 100 colorimetric tests

detection method

colorimetric

相关疾病

cancer; gastrointestinal diseases

储存温度

−20°C

Gene Information

human ... GLUD1(2746) , GLUD2(2747)
mouse ... GLUD1(14661)
rat ... GLUD1(24399)

相关类别

一般描述

谷氨酸脱氢酶 (GDH) 是一种线粒体酶，催化谷氨酸可逆性氧化脱氨生成 α-酮戊二酸，作为合成代谢和分解代谢途径之间的关键链接。在哺乳动物中，GDH受变构调节，在肝脏、肾脏、大脑和胰腺中具有较高的活性。血清中的 GDH 活性可用于区分肝脏炎症所致的肝脏疾病（未显示血清 GDH 活性升高）和导致肝细胞坏死的疾病（导致血清 GDH 升高）。

应用

谷氨酸脱氢酶 (GDH) 活性测定试剂盒已用于测定谷氨酸脱氢酶的酶活性。

特点和优势

与高通量处理系统兼容。

适用性

适用于检测血清或组织及细胞提取液中的谷氨酸脱氢酶 (GDH) 活性。

原理

通过偶联酶试验可测定 GDH 活性，其中谷氨酸被 GDH 消耗，生成 NADH，NADH 与探针反应生成与 GDH 活性成比例的比色 (450 nm) 产物。一个单位的GDH 在37℃下pH 7.6 时 每分钟将产生1.0μ摩尔NADH的酶量。

储存分类代码

10 - Combustible liquids

法规信息

常规特殊物品

分析证书(COA)

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示例

T1503
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其它示例：

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