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Merck
CN

MAK107

LCAT 活性检测试剂盒

Supplied by Roar Biomedical, Inc.

别名:

Lecithin:胆固醇酰基转移酶活性检测试剂盒

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关于此项目

UNSPSC Code:
12161503
EC Number:
200-659-6
NACRES:
NA.84

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产品名称

LCAT 活性检测试剂盒, Supplied by Roar Biomedical, Inc.

usage

sufficient for 100 fluorometric tests

application(s)

pharmaceutical

detection method

fluorometric

relevant disease(s)

cardiovascular diseases

storage temp.

−20°C

Gene Information

human ... LCAT(3931)

Analysis Note

了解更多关于Roar检测试剂盒在脂蛋白代谢中的研究。

Application

LCAT活性测定试剂盒用于测定血浆样品中的卵磷脂胆固醇酰基转移酶活性。
该方法的应用包括高通量筛选、作用机制研究和构效关系（SAR）研究。
适用于测定血浆或血清中LCAT的磷脂酶活性。

Biochem/physiol Actions

LCAT活性检测试剂盒 是用于测定LCAT（卵磷脂胆固醇酰基转移酶）磷脂酶活性的荧光检测法(λEx=390 nm/λEm=470 nm)。该测定可以通过用碘乙酸盐或另一种光谱上良性（非Ellman′s试剂）LCAT抑制剂抑制LCAT进行验证。

Features and Benefits

兼容高通量操作系统。

General description

血浆蛋白卵磷脂胆固醇酰基转移酶（LCAT）可催化酰基从磷脂酰胆碱的sn2位转移到胆固醇的3-羟基，从而生成胆固醇酯。这种酶活性发生在高密度脂蛋白（HDL）的表面。由LCAT生成的胆固醇酯可以填充到HDL的核心。

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

存储类别

3 - Flammable liquids

flash_point_f

49.5 °F

flash_point_c

9.7 °C

法规信息

危险化学品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
RBH5080V
RBH5080V
RBH5078V
RBH5076V
RBH5074V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Are products MAK107 and MAK108 compatible with mouse serum?

    Yes, but please be aware of possible sample hemolysis. Depending on the method of mouse sample collection, hemolysis may be common, which can interfere with fluorescence emission via color quenching.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Anatol Kontush et al.
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The purpose of this study was to define heterogeneity in the molecular profile of lipids, including sphingomyelin and sphingosine-1-phosphate, among physicochemically-defined HDL subpopulations and potential relevance to antiatherogenic biological activities of dense HDL3. The molecular profile of lipids (cholesteryl esters
E Nobécourt et al.
Diabetologia, 48(3), 529-538 (2005-02-25)
Elevated oxidative stress, hyperglycaemia, and dyslipidaemia involving low levels of HDL particles are key proatherogenic factors in type 2 diabetes mellitus. We examined the relationship of oxidative stress, and the degree of glycaemia and triglyceridaemia, to antioxidative function of HDL
Reversal of high fat diet-induced obesity through modulating lipid metabolic enzymes and inflammatory markers expressions in rats.
Uddandrao V V S, et al.
Archives of Physiology and Biochemistry, 1-7 (2018)
Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats.
Naidu P B, et al.
Molecular and Cellular Endocrinology, 419, 139-147 (2016)
Akbar Jafarnejad et al.
The Journal of pharmacology and experimental therapeutics, 324(2), 850-857 (2007-11-15)
Diabetes mellitus has been classified as a conformational disease because of changes induced in the structure and function of proteins due to hyperglycemia. In this study, we investigated the effect of high-dose and long-term use of acetyl salicylic acid (ASA)
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