用途
sufficient for 100 fluorometric tests
应用
pharmaceutical
检测方法
fluorometric
相关疾病
cardiovascular diseases
储存温度
2-8°C
基因信息
human ... MTTP(4547)
一般描述
微粒体甘油三酯转移蛋白（MTP），一种存在于肝脏中的膜结合蛋白，可在极低密度脂蛋白（VLDL）的组装和分泌中起到重要作用。MTP对于肠内乳糜微粒的组装和分泌也是必需的。该蛋白有助于甘油三酯（TG）、胆固醇酯（CE）和磷脂酰胆碱（PC）在磷脂表面之间的转移。 MTP基因中的突变可导致无β脂蛋白血症。
应用
MTP活性检测试剂盒已被用于测量微粒体甘油三酯转移蛋白（MTP）的活性。
适用于测量细胞裂解液或组织匀浆液中微粒体[甘油三酯]转移蛋白（MTP）的活性，或用于筛选MTP活性抑制剂。
生化/生理作用
MTP活性检测试剂盒是一种灵敏的均质荧光检测方法，可用于细胞裂解物或组织匀浆中中MTP活性的连续测量。该试剂盒包括能够检测 MTP 介导的中性脂质转移的专有底物。 这种转移活性导致荧光强度增加（λEx=465 nm/λEm=535 nm）。
特点和优势
兼容高通量操作系统。
储存分类代码
10 - Combustible liquids
法规信息
常规特殊物品
Thi Thu Trang Tran et al.
The Journal of biological chemistry, 291(31), 16328-16338 (2016-06-04)
The worldwide prevalence of metabolic diseases is increasing, and there are global recommendations to limit consumption of certain nutrients, especially saturated lipids. Insulin resistance, a common trait occurring in obesity and type 2 diabetes, is associated with intestinal lipoprotein overproduction.
J Massart et al.
British journal of pharmacology, 165(5), 1361-1374 (2011-07-12)
Pentoxifylline is in clinical trials for non-alcoholic fatty liver disease and diabetic nephropathy. Metabolic and hepatic effects of pentoxifylline were assessed in a murine model of obesity and type 2 diabetes. Pentoxifylline (100 mg·kg(-1) ·day(-1)) was administered for 4 days
J Estellé et al.
Animal genetics, 40(6), 813-820 (2009-06-06)
Despite the economic interest of the fatty acid profile in pigs, no gene has been convincingly associated with this trait so far. Here, the porcine microsomal triglyceride transfer protein (MTTP) gene, which plays a crucial role in the assembly of
Yuan-Lung Cheng et al.
Clinical science (London, England : 1979), 125(9), 439-448 (2013-05-11)
HCV (hepatitis C virus) infection affects an estimated 180 million people in the world's population. Adverse effects occur frequently with current standard treatment of interferon and ribavirin, while resistance of new direct anti-viral agents, NS3 protease inhibitors, is a major
Qinyuan Ye et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 43(10), 1115-1123 (2013-02-21)
To investigate the role of Cytochrome P4502E1 in sensitizing Kupffer cells to lipopolysaccharide (LPS)-mediated inflammation after ethanol induction. Sprague-Dawley rats were fed a liquid ethanol diet, control diet or ethanol diet supplemented with CYP2E1 inhibitor, chlormethiazole (CMZ), for 4 weeks. Hepatic
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持