产品名称
酮体检测试剂盒, sufficient for 200 tests (UV)
usage
sufficient for 200 tests (UV)
feature
This kit is sufficient for up to 100 assays of 3-hydroxybutyric acid (BOH) and up to 100 assays of acetoacetic acid (AcAc) in 96 well plates.
detection method
colorimetric
relevant disease(s)
endocrinological disorders, diabetes; neonatal diseases; pediatric diseases; cancer
storage temp.
−20°C
Application
可用于检测血清、血浆、尿液及其他生物样品中的酮体（乙酰乙酸和3-羟基丁酸）。
酮体测定法已用于测量人肝癌细胞系 HepG2 培养基中酮体的释放。
Biochem/physiol Actions
在本试剂盒中，使用基于 3-羟基丁酸脱氢酶催化反应的酶分析法测定 AcAc 和 BOH 水平，其中在 340 nm 处测定的 NADH 吸光度更改与 AcAc 和 BOH 浓度直接相关。
Features and Benefits
兼容高通量的操作系统。
General description
酮体 3-羟基丁酸 (BOH) 和乙酰乙酸 (AcAc) 主要在肝脏中由脂肪酸氧化生成 ，正常情况下在尿液和血液中浓度较低。血液中酮体浓度升高可能导致代谢性酸中毒，这与糖尿病、儿童期低血糖、生长激素缺乏症、酒精或水杨酸盐中毒以及先天性代谢缺陷相关。
存储类别
10 - Combustible liquids
法规信息
常规特殊物品
此项目有
Kim J Shimy et al.
Journal of the Endocrine Society, 4(7), bvaa062-bvaa062 (2020-07-16)
According to the carbohydrate-insulin model of obesity, an elevated insulin-to-glucagon ratio in response to a high-carbohydrate diet directs metabolic fuels toward storage, resulting in lower circulating energy. To determine differences in total circulating energy post-meal related to dietary carbohydrate. Ancillary
Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes.
Kanikarla M, et al.
Free Radical Biology & Medicine, 95, 268-277 (2016)
Zachary M Augur et al.
Frontiers in nutrition, 5, 91-91 (2018-10-24)
Introduction: Temozolomide (TMZ) is part of the standard of care for treating glioblastoma multiforme (GBM), an aggressive primary brain tumor. New approaches are needed to enhance therapeutic efficacy and reduce toxicity. GBM tumor cells are dependent on glucose and glutamine
Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease.
Dedkova E N and Lothar A B
Frontiers in Physiology, 5, 260-260 (2014)
Catia Martins et al.
Obesity (Silver Spring, Md.), 28(12), 2331-2338 (2020-11-25)
The purpose of this study was to examine whether the degree of ketosis, measured as plasma β-hydroxybutyrate (βHB) in fasting, was associated with changes in appetite feelings and plasma concentration of appetite-related hormones after weight loss. A total of 87
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