用途
sufficient for 100 fluorometric tests
检测方法
fluorometric
相关疾病
cardiovascular diseases
储存温度
−20°C
基因信息
human ... REN(5972)
rat ... REN(24715)
一般描述
肾素，也称为血管紧张素原酶，是一种天冬氨酰蛋白酶，可切割血管紧张素原，形成血管紧张素 I，这是肾素-血管紧张素系统（RAS）的初始和限速步骤。该系统在血压和体液平衡的调节中起关键作用。由于血管收缩和液体潴留增加，肾素活性增加可导致高血压。肾素抑制剂可用于高血压的治疗。
应用
肾素检测试剂盒已用于测定肾素的活性。
肾素检测试剂盒提供了一种方便、简单的检测方法，适于筛查多种样品中的肾素活性，或用于筛选肾素抑制剂。
生化/生理作用
肾素的活性是通过含有荧光猝灭剂的专有荧光共振能量转移（FRET）肽测定的。肾素切割肽会产生一种荧光产物（λex = 540/λem = 590 nm）。该测定的灵敏度约是基于 EDANS/DABCYL 的测定的 50 倍。
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Árpád Kovács et al.
American journal of physiology. Heart and circulatory physiology, 310(11), H1671-H1682 (2016-04-10)
Hypertension (HTN) is a major risk factor for heart failure. We investigated the influence of HTN on cardiac contraction and relaxation in transgenic renin overexpressing rats (carrying mouse Ren-2 renin gene, mRen2, n = 6). Blood pressure (BP) was measured.
Yoshio T, et al.
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research (2015)
Christopher M Ferguson et al.
Cells, 10(4) (2021-04-04)
Percutaneous transluminal renal angioplasty (PTRA) confers clinical and mortality benefits in select 'high-risk' patients with renovascular disease (RVD). Intra-renal-delivered extracellular vesicles (EVs) released from mesenchymal stem/stromal cells (MSCs) protect the kidney in experimental RVD, but have not been compared side-by-side
Yamei Jiang et al.
Frontiers in immunology, 13, 940093-940093 (2022-10-08)
Extracellular vesicles (EVs) obtain properties of immunomodulation and tissue repair from their parental mesenchymal stem cells (MSCs), and upon delivery may be associated with fewer adverse events. EVs derived from adipose-tissue MSCs restored kidney function by attenuating kidney inflammation in
Yong Zhang et al.
Frontiers in physiology, 13, 876777-876777 (2022-05-20)
The therapeutic potential of 2-Methoxyestradiol (2ME2) is evident in cardiovascular disease. Our laboratory has previously demonstrated the mechanism involved in the 2ME2 regulation of angiotensin type 1 receptor (AT1R) in vitro. However, 2ME2 regulation of angiotensin receptors and its effects
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持