应用
cosmetics
food and beverages
pharmaceutical
检测方法
fluorometric
相关疾病
cardiovascular diseases
储存温度
−20°C
一般描述
胆固醇逆向转运 (RCT) 是通过转运至肝脏及其粪便排泄，降低外周脂质负荷的机制。RCT 的第一步是动脉粥样硬化斑块中巨噬细胞源性泡沫细胞的胆固醇流出。胆固醇外流对于维持动脉壁净胆固醇平衡和减少由富含脂质的巨噬细胞触发的促炎症反应至关重要。
应用
胆固醇外流测定试剂盒已用于胆固醇外流测定。
适用于细胞内胆固醇外流的测定。
生化/生理作用
胆固醇外排检测试剂盒是一种高通量筛选分析试剂盒，通过荧光标记的胆固醇检测细胞中的胆固醇外排(λEx = 482 nm/ λEm = 515 nm)。适用于血清、分离或重组脂蛋白样本。也可根据胆固醇外排作用筛选小分子，因此可作为有价值的药物发现工具。
特点和优势
兼容高通量操作系统。
仅试剂盒组分
产品编号
说明
- Labeling Reagent
- Equilibration Buffer
- Reagent A
- Reagent B
- Cell Lysis Buffer
- Positive Control
- Serum Treatment Reagent
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
10 - Combustible liquids
闪点(°F)
188.6 °F - closed cup
闪点(°C)
87 °C - closed cup
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Anastasia Darwitan et al.
Advanced healthcare materials, 9(14), e2000465-e2000465 (2020-06-17)
Atherosclerosis is a chronic disease that can lead to life-threatening events such as myocardial infarction and stroke, is characterized by the build-up of lipids and immune cells within the arterial wall. It is understood that inflammation is a hallmark of
Marc Clément et al.
Circulation, 134(14), 1039-1051 (2016-09-03)
Atherosclerotic lesion expansion is characterized by the development of a lipid-rich necrotic core known to be associated with the occurrence of complications. Abnormal lipid handling, inflammation, and alteration of cell survival or proliferation contribute to necrotic core formation, but the
Bariatric surgery improves lipoprotein profile in morbidly obese patients by reducing LDL cholesterol, apoB, and SAA/PON1 ratio, increasing HDL cholesterol, but has no effect on cholesterol efflux capacity.
Kjellmo C A, et al.
Journal of Clinical Lipidology, 12(1), 193-202 (2018)
Christian Abendstein Kjellmo et al.
Journal of clinical lipidology, 12(1), 193-202 (2017-11-18)
Bariatric surgery has been shown to reduce cardiovascular events and cause-specific mortality for coronary artery disease in obese patients. Lipoprotein biomarkers relating to low-density lipoprotein (LDL), high-density lipoprotein (HDL), their subfractions, and macrophage cholesterol efflux have all been hypothesized to
Lipoprotein apheresis affects lipoprotein particle subclasses more efficiently compared to the PCSK9 inhibitor evolocumab, a pilot study.
Lappeg?rd K T, et al.
Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis, 57(1), 91-96 (2018)
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