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Merck
CN

MAK192

胆固醇外流检测试剂盒

Sufficient for 100 Fluorometric tests

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UNSPSC Code:
12161503
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application(s)

cosmetics
food and beverages
pharmaceutical

detection method

fluorometric

relevant disease(s)

cardiovascular diseases

storage temp.

−20°C

General description

胆固醇逆向转运 (RCT) 是通过转运至肝脏及其粪便排泄,降低外周脂质负荷的机制。RCT 的第一步是动脉粥样硬化斑块中巨噬细胞源性泡沫细胞的胆固醇流出。胆固醇外流对于维持动脉壁净胆固醇平衡和减少由富含脂质的巨噬细胞触发的促炎症反应至关重要。

Application

胆固醇外流测定试剂盒已用于胆固醇外流测定。
适用于细胞内胆固醇外流的测定。

Biochem/physiol Actions

胆固醇外排检测试剂盒是一种高通量筛选分析试剂盒,通过荧光标记的胆固醇检测细胞中的胆固醇外排(λEx = 482 nm/ λEm = 515 nm)。适用于血清、分离或重组脂蛋白样本。也可根据胆固醇外排作用筛选小分子,因此可作为有价值的药物发现工具。

Features and Benefits

兼容高通量操作系统。

仅试剂盒组分

产品编号
说明

  • Labeling Reagent

  • Equilibration Buffer

  • Reagent A

  • Reagent B

  • Cell Lysis Buffer

  • Positive Control

  • Serum Treatment Reagent

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

存储类别

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis, 57(1), 91-96 (2018)
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Journal of cellular and molecular medicine, 23(8), 5259-5269 (2019-05-24)
The formation of fat-laden foam cells, which contributes to the fatty streaks in the plaques of atheromas, is an important process in atherosclerosis. Vascular smooth muscle cells (VSMCs) are a critical origin of foam cells. However, the mechanisms that underlie
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Circulation, 134(14), 1039-1051 (2016-09-03)
Atherosclerotic lesion expansion is characterized by the development of a lipid-rich necrotic core known to be associated with the occurrence of complications. Abnormal lipid handling, inflammation, and alteration of cell survival or proliferation contribute to necrotic core formation, but the
Anastasia Darwitan et al.
Advanced healthcare materials, 9(14), e2000465-e2000465 (2020-06-17)
Atherosclerosis is a chronic disease that can lead to life-threatening events such as myocardial infarction and stroke, is characterized by the build-up of lipids and immune cells within the arterial wall. It is understood that inflammation is a hallmark of

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