产品名称
唾液酸检测试剂盒, sufficient for 100 colorimetric or fluorometric tests
usage
sufficient for 100 colorimetric or fluorometric tests
detection method
colorimetric
fluorometric
relevant disease(s)
cancer; cardiovascular diseases; hematological disorder
storage temp.
−20°C
Application
- 有或无胃肠道表现的中度COVID-19患者血清总唾液酸的评估。：研究检测了COVID-19患者的血清唾液酸水平，了解疾病对胃肠道的影响（Haroun et al., 2022）。
适用于定量测定血清、血浆、唾液、乳汁中游离唾液酸和总唾液酸(NANA)的含量，并评估药物对唾液酸的影响。
Biochem/physiol Actions
该唾液酸检测试剂盒采用改良的Warren测定法。其中唾液酸被氧化成为甲酰丙酮酸，与硫代巴比妥酸反应形成粉红色产物。比色(549nm)/荧光(λex = 555nm/λem = 585nm)产物与样本中的唾液酸浓度直接成正比。
General description
唾液酸是九碳酸性糖与 N-或 O-取代衍生物的总名称。这些糖类中最常见的是 N-乙酰神经氨酸 (NANA)。它们与碳水化合物结合并定位在细胞膜上。唾液酸广泛分布于哺乳动物组织和体液中，包括血清。 唾液酸化寡糖已被证明表现出抗病毒属性，也已知会影响血液凝固和胆固醇水平。体液中的唾液酸水平也是诊断癌症的重要标志物。
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A - STOT SE 3
target_organs
Respiratory system
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
Sialic acids: fascinating sugars in higher animals and man.
Schauer R.
Zoology (Jena, Germany), 107(1), 49-64 (2004)
Sialic Acids
Varki A, et al.
Essentials Of Glycobiology. 2nd Edition. (2009)
Salivary total sialic acid levels increase in breast cancer patients: a preliminary study.
Ozturk L K, et al.
Medicinal Chemistry, 7(5), 443-447 (2011)
Alice J Stelfox et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(43), 21514-21520 (2019-10-09)
The bat-borne paramyxovirus, Sosuga virus (SosV), is one of many paramyxoviruses recently identified and classified within the newly established genus Pararubulavirus, family Paramyxoviridae The envelope surface of SosV presents a receptor-binding protein (RBP), SosV-RBP, which facilitates host-cell attachment and entry.
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