Merck
CN

MTOX1006

Sigma-Aldrich

BCRP/MRP2 Double Knockout Caco-2 Cells

one vial

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别名:
C2BBe1 Cells BCRP/MRP2 (-/-/-/-,-/-/-/-)
NACRES:
NA.81

生物来源

human male colorectal tissue (Source disease: adenocarcinoma)

质量水平

形式

liquid

技术

drug transporter assay: suitable
permeability assay: suitable

OMIM登记号

应用

ADME/TOX

储存温度

−196°C

基因信息

一般描述

The C2BBe1 cells, a subclone of Caco-2 cells, correspond to ATCC CRL-2102. The BCRP and MRP2 knockout C2BBe1 cells are adenocarcinoma, epithelial cells from a human caucasian male (aged 72 years) with functional double knockout of the ABCG2 and ABCC2 (BCRP/MRP2) efflux transporters.

特点和优势

The Caco-2 subclone C2BBe1 cells are ideal for transporter analysis as they express multiple transporters, are human derived, and grow in a homogenous monolayer that forms tight juntions which is necessary for efflux ratio analysis. Other benefits include:

  • A functional double knockout of the BCRP gene and MRP2 gene eliminates the reliance on chemical inhibitors to determine if a compound is an MDR1 substrate
  • The vial format enables the BCRP and MRP2 knockout cells to be included in standard drug transporter protocols
  • Human assay with no interference from animal inhibitors
  • Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality

免责声明

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

试剂盒组分也可单独购买

产品编号
说明
化学品安全说明书

  • MTOX1006BCRP/MRP2 Double Knockout Caco-2 Cells, one vial 1 vial化学品安全说明书

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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