N0287
NNC 55-0396 水合物
≥98% (HPLC)
别名:
NNC55-0396, （1S,2S）-2-（2-（N-[（3-苯并咪唑-2-基）丙基]-N-甲基氨基）乙基）-6-氟-1,2,3,4-四氢-1-异丙基-2-萘基环丙烷羧酸酯二盐酸盐 水合物
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关于此项目
经验公式（希尔记法）:
C30H40Cl2FN3O2 · xH2O
分子量:
564.56 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
颜色
white
溶解性
H2O: >10 mg/mL
创始人
Roche
储存温度
2-8°C
SMILES字符串
O.Cl.Cl.CC(C)[C@H]1c2ccc(F)cc2CC[C@@]1(CCN(C)CCCc3nc4ccccc4[nH]3)OC(=O)C5CC5
InChI
1S/C30H38FN3O2.2ClH.H2O/c1-20(2)28-24-13-12-23(31)19-22(24)14-15-30(28,36-29(35)21-10-11-21)16-18-34(3)17-6-9-27-32-25-7-4-5-8-26(25)33-27;;;/h4-5,7-8,12-13,19-21,28H,6,9-11,14-18H2,1-3H3,(H,32,33);2*1H;1H2/t28-,30-;;;/m0.../s1
InChI key
ICVIUVXDXJUZRQ-SHQDEPIZSA-N
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present
Xianjie Wen et al.
PloS one, 8(5), e62942-e62942 (2013-05-10)
There is concern regarding neurotoxicity induced by the use of local anesthetics. A previous study showed that an overload of intracellular calcium is involved in the neurotoxic effect of some anesthetics. T-type calcium channels, which lower the threshold of action
Luping Huang et al.
The Journal of pharmacology and experimental therapeutics, 309(1), 193-199 (2004-01-14)
Mibefradil is a Ca2+ channel antagonist that inhibits both T-type and high-voltage-activated Ca2+ channels. We previously showed that block of high-voltage-activated channels by mibefradil occurs through the production of an active metabolite by intracellular hydrolysis. In the present study, we
Jesús Espinal-Enríquez et al.
Scientific reports, 7(1), 4236-4236 (2017-06-28)
Spermatozoa sea urchin swimming behaviour is regulated by small peptides from the egg outer envelope. Speract, such a peptide, after binding to its receptor in Strongylocentrotus purpuratus sperm flagella, triggers a signaling pathway that culminates with a train of intracellular
T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines
Huang W, et al.
Journal of Experimental & Clinical Cancer Research, 34(1), 1-1 (2015)
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