N1016
尼美舒利
别名:
N-（4-硝基-2-苯氧基苯基）甲磺酰胺
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关于此项目
经验公式（希尔记法）:
C13H12N2O5S
化学文摘社编号:
分子量:
308.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
257-431-4
MDL number:
InChI key
HYWYRSMBCFDLJT-UHFFFAOYSA-N
InChI
1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
SMILES string
CS(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(=O)=O
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
solubility
ethanol: 50 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... ALB(213), PTGS1(5742), PTGS2(5743)
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相关类别
Biochem/physiol Actions
高选择性环氧化酶-2 抑制剂。
尼美舒利可作为其他非甾体抗炎药 (NSAID) 的替代品，用于治疗骨关节炎的疼痛和炎症。能抗炎、镇痛、解热活性。
General description
尼美舒利是一种非甾体抗炎药，属于磺胺类药物。
Application
尼美舒利已被用作反应混合物的成分，用于测定鸡脾脏中环氧合酶 (COX) 的活性。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Effects of dietary fish oil on NF
Yang X, et al.
The Journal of animal ecology, 20(3), 206-223 (2011)
Renata P Raffin et al.
Journal of biomedical nanotechnology, 8(2), 309-315 (2012-04-21)
Lipid nanoparticles are drug delivery systems able to increase bioavailability of poorly soluble drugs. They can be prepared with different lipid materials, especially natural lipids. Shea butter is a natural lipid obtained from the Butyrospermum parkii seed and rich in
Brijesh Kumar Singh et al.
PloS one, 7(4), e34200-e34200 (2012-04-18)
Nimesulide, an anti-inflammatory and analgesic drug, is reported to cause severe hepatotoxicity. In this study, molecular mechanisms involved in deranged oxidant-antioxidant homeostasis and mitochondrial dysfunction during nimesulide-induced hepatotoxicity and its attenuation by plant derived terpenes, camphene and geraniol has been
Yuan Yuan et al.
International journal of pharmaceutics, 430(1-2), 114-119 (2012-04-17)
Poloxamer 407 has excellent thermo-sensitive gelling properties. Nevertheless, these gels possess inadequate poor bioadhesiveness and high permeability to water, which limited its' application as a thermoresponsive matrix. The main aim of the present investigation was to develop thermosensitive and mucoadhesive
Nimesulide
Davis R and Brogden R N
Drugs, 48(3), 431-454 (1994)
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