NSCI

Name: NSCI
Brand: SIGMA

≥97% (HPLC), solid

别名:

1-(4-Methyoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₆H₂₅N₃O₆S

CAS Number:

872254-32-5

分子量:

507.56

UNSPSC代码:

12352200

PubChem化学物质编号:

24897488

NACRES:

NA.77

质量水平

100

方案

≥97% (HPLC)

表单

solid

溶解性

DMSO: >10 mg/mL
H₂O: insoluble

储存温度

−20°C

SMILES字符串

COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N4CCC[C@H]4COc5cccnc5)cc1

InChI

1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-17H2,1H3/t19-/m0/s1

InChI key

XDHJBIYJRNFDKS-IBGZPJMESA-N

基因信息

human ... CASP1(834), CASP3(836), CASP6(839), CASP7(840), SUMO1(7341)

应用

NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells. It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4⁺) and cluster of differentiation 8 (CD8⁺) T cells from pleural effusions, mononuclear cells (PEMCs).

生化/生理作用

1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor.

特点和优势

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.