N1530
诺米芬辛 马来酸盐
dopamine uptake inhibitor , powder
别名:
1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate salt
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关于此项目
经验公式（希尔记法）:
C16H18N2 · C4H4O4
化学文摘社编号:
分子量:
354.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
251-223-7
MDL number:
Form:
powder
产品名称
诺米芬辛 马来酸盐,
form
powder
Quality Segment
SMILES string
[H]\C(=C(/[H])C(O)=O)C(O)=O.CN1CC(c2ccccc2)c3cccc(N)c3C1
InChI
1S/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
GEOCVSMCLVIOEV-BTJKTKAUSA-N
Gene Information
human ... DBH(1621), SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)
Application
Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.
Biochem/physiol Actions
Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter, at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves