N158
Naftopidil hydrochloride hydrate
solid
别名:
4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate, KT-611
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关于此项目
经验公式（希尔记法）:
C24H28N2O3 · xHCl · yH2O
化学文摘社编号:
分子量:
392.49 (anhydrous free base basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
产品名称
Naftopidil hydrochloride hydrate, solid
InChI key
INIDYCYXDNFBSV-UHFFFAOYSA-N
SMILES string
O.Cl.COc1ccccc1N2CCN(CC2)CC(O)COc3cccc4ccccc34
InChI
1S/C24H28N2O3.ClH.H2O/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;1H;1H2
form
solid
color
white
solubility
methanol: >10 mg/mL
H2O: insoluble
Quality Level
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
Biochem/physiol Actions
α1-Adrenoceptor antagonist; antihypertensive.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Hideki Sakai et al.
Hinyokika kiyo. Acta urologica Japonica, 57(1), 7-13 (2011-02-10)
A total of 100 patients with benign prostatic hyperplasia (BPH) and overactive bladder (OAB) symptoms (BPH/OAB), enrolled between June 2006 to March 2008, were randomly divided into 2 groups of morning medication (M) and evening medication (E) groups, then 50
Teruhiko Yokoyama et al.
International journal of urology : official journal of the Japanese Urological Association, 18(3), 225-230 (2011-01-29)
The aim of the present study was to explore the effects of three different types of alpha-1 adrenoceptor blockers (α1-blocker) on lower urinary tract symptoms (LUTS), erectile dysfunction (ED) and ejaculatory dysfunction (EjD) in patients with benign prostatic hyperplasia. A
Eriko Masachika et al.
Anticancer research, 33(3), 887-894 (2013-03-14)
Naftopidil, an α1-adrenoceptor blocker, has been clinically used for the treatment of benign prostate hyperplasia and hypertension. Emerging evidence has shown that naftopidil exhibits an antitumor effect on a variety of cancer types including prostate cancer. The aim of the
S Yamada et al.
Life sciences, 50(2), 127-135 (1992-01-01)
Binding properties of naftopidil and alpha 1-adrenoceptor antagonists to alpha-adrenoceptors in prostates from benign prostatic hypertrophy (BPH) were characterized by radioreceptor assays using [3H]prazosin and [3H]rauwolscine. Specific binding of [3H]prazosin and [3H]rauwolscine in human prostatic membranes was saturable and of
G Sponer et al.
Journal of cardiovascular pharmacology, 20(6), 1006-1013 (1992-12-01)
The interaction of naftopidil with adrenoceptors was studied in comparison to standard drugs. Naftopidil binds specifically to alpha 1-adrenoceptors. The Ki values are 58.3 nM for naftopidil, 0.43 nM for prazosin, and 197 nM for urapidil. The affinities of naftopidil
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