N158
Naftopidil hydrochloride hydrate
solid
别名:
4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate, KT-611
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关于此项目
经验公式（希尔记法）:
C24H28N2O3 · xHCl · yH2O
化学文摘社编号:
分子量:
392.49 (anhydrous free base basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
INIDYCYXDNFBSV-UHFFFAOYSA-N
SMILES string
O.Cl.COc1ccccc1N2CCN(CC2)CC(O)COc3cccc4ccccc34
InChI
1S/C24H28N2O3.ClH.H2O/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;1H;1H2
form
solid
color
white
solubility
methanol: >10 mg/mL, H2O: insoluble
Quality Level
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
Biochem/physiol Actions
α1-Adrenoceptor antagonist; antihypertensive.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Xiawen Liu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907, 140-145 (2012-10-03)
Two bioanalytical HPLC methods (chiral solid phases (CSPs) HPLC and pre-column derivatization HPLC) were developed and validated for the determination of naftopidil enantiomers in rat plasma. Analytes were extracted from biomaterials by liquid-liquid extraction. The pre-column derivatization HPLC method employed
Katsumi Kadekawa et al.
Life sciences, 92(20-21), 1024-1028 (2013-04-16)
Alpha1D-adrenoceptors (α1D-ARs) located in the spinal cord are involved in the control of lower urinary tract function. In order to clarify the effect of α1D-ARs on storage function in the spinal cord, we examined the effect of oral administration and
Tomokazu Sazuka et al.
Journal of endourology, 26(9), 1216-1220 (2012-04-11)
To examine the efficacy of an alpha-1 blocker and its correlation to structural alteration of the prostatic urethra and the loss of energy in the urine flow using a virtual urethra processed from an endoscopic video image. Video images of
Shui Gen Zhou et al.
World journal of urology, 29(6), 767-771 (2011-08-17)
To compare the efficacy of α(1)D-receptor antagonist Naftopidil and α(1)A/D-receptor antagonist Tamsulosin in management of distal ureteral stones. A total of 131 patients with distal ureteral stones were included in the study from December 2008 to September 2010. The patients
Satoshi Tatemichi et al.
Urology, 80(2), 486-486 (2012-06-09)
To compare the effects of four α(1)-adrenoceptor (AR) subtype-selective antagonists on ejaculatory function in rats to investigate whether the differences in their modes of action-based on their selectivities for the α(1A)-AR subtype-would be related to the prevalence of ejaculation disorder
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