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安全信息

N1628

Sigma-Aldrich

新生霉素 钠盐

≥90% (HPLC)

别名:

Albamycin, Albamycin Sodium, Cathomycin sodium

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About This Item

经验公式(希尔记法):
C31H35N2NaO11
CAS Number:
分子量:
634.61
Beilstein:
3892910
EC 号:
UNSPSC代码:
51286504
PubChem化学物质编号:
NACRES:
NA.85

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生物来源

(STREPTOMYCES NIVEUS)

质量水平

方案

≥90% (HPLC)

表单

powder

储存条件

(Tightly closed. Dry. )

颜色

white to yellow

抗生素抗菌谱

Gram-positive bacteria

作用机制

DNA synthesis | interferes
enzyme | inhibits

储存温度

2-8°C

SMILES字符串

[Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C

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一般描述

Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.

应用

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.
Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used:
  • in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA[1]
  • in the research on the efficacy of probiotics[2][3]
  • in the research on the efficacy of human monocytes and dendritic cells for T-cell replication[4]

生化/生理作用

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.
Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB[1].

特点和优势

High quality antibiotic suitable for mulitple research applications

储存及稳定性

Stored in frozen aliquots, Keep container tightly closed in a dry and well-ventilated place. Light sensitive

其他说明

For additional information on our range of Biochemicals, please complete this form.

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警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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  • 历史批次信息供参考:

    分析证书(COA)

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