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Merck
CN

N1628

Sigma-Aldrich

新生霉素 钠盐

≥90% (HPLC)

别名:

Albamycin, Albamycin Sodium, Cathomycin sodium

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关于此项目

经验公式（希尔记法）:
C31H35N2NaO11
化学文摘社编号:
1476-53-5
分子量:
634.61
Beilstein:
3892910
EC 号:
216-023-6
UNSPSC代码:
51286504
PubChem化学物质编号:
24897508
NACRES:
NA.85

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生物来源

(STREPTOMYCES NIVEUS)

质量水平

200

方案

≥90% (HPLC)

表单

powder

储存条件

(Tightly closed. Dry. )

颜色

white to yellow

抗生素抗菌谱

Gram-positive bacteria

作用机制

DNA synthesis | interferes
enzyme | inhibits

储存温度

2-8°C

SMILES字符串

[Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C

InChI

1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1

InChI key

AXOUUAINTJNFRS-UHFFFAOYSA-N

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相关类别

一般描述

Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.

应用

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.
Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used:
  • in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA
  • in the research on the efficacy of probiotics
  • in the research on the efficacy of human monocytes and dendritic cells for T-cell replication

生化/生理作用

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.
Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.

特点和优势

High quality antibiotic suitable for mulitple research applications

制备说明

Stored in frozen aliquots, Keep container tightly closed in a dry and well-ventilated place. Light sensitive

其他说明

For additional information on our range of Biochemicals, please complete this form.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H317,H319

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000480155
0000480155
0000469111
0000469111
0000469114

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Temporal effects of lactic acid bacteria probiotic culture on Salmonella in neonatal broilers
Higgins et al.
Poultry Science, Aug;86(8):, 1662-1666 (2007)
A Maxwell
Molecular microbiology, 9(4), 681-686 (1993-08-01)
The coumarin group of antibiotics have as their target the bacterial enzyme DNA gyrase. The drugs bind to the B subunit of gyrase and inhibit DNA supercoiling by blocking the ATPase activity. Recent data show that the binding site for
Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication
Voorhis et al.
The Journal of Experimental Medicine, 58, 174-191 (1983)
Evaluation of a Lactobacillus-based probiotic culture for the reduction of Salmonella enteritidis in neonatal broiler chicks
Higgins et al.
Poultry Science, 87, 27-31 (2008)
Yosef D Huberman et al.
Poultry science, 98(6), 2422-2431 (2019-01-29)
Salmonellosis caused by Salmonella Enteritidis is a widespread zoonosis and poultry products are an important source of infection. This study was carried out to evaluate the protection of different vaccination schedules in layers using a live commercial attenuated Salmonella Enteritidis
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