生物来源
(STREPTOMYCES NIVEUS)
质量水平
方案
≥90% (HPLC)
表单
powder
储存条件
(Tightly closed. Dry. )
颜色
white to yellow
抗生素抗菌谱
Gram-positive bacteria
作用机制
DNA synthesis | interferes
enzyme | inhibits
储存温度
2-8°C
SMILES字符串
[Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C
InChI
1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
InChI key
AXOUUAINTJNFRS-UHFFFAOYSA-N
正在寻找类似产品? 访问 产品对比指南
一般描述
Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.
应用
For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.
Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used:
- in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA
- in the research on the efficacy of probiotics
- in the research on the efficacy of human monocytes and dendritic cells for T-cell replication
生化/生理作用
Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.
Antimicrobial spectrum: Gram-positive bacterial.
Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.
特点和优势
High quality antibiotic suitable for mulitple research applications
制备说明
Stored in frozen aliquots, Keep container tightly closed in a dry and well-ventilated place. Light sensitive
其他说明
For additional information on our range of Biochemicals, please complete this form.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
Temporal effects of lactic acid bacteria probiotic culture on Salmonella in neonatal broilers
Higgins et al.
Poultry Science, Aug;86(8):, 1662-1666 (2007)
Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication
Voorhis et al.
The Journal of Experimental Medicine, 58, 174-191 (1983)
Evaluation of a Lactobacillus-based probiotic culture for the reduction of Salmonella enteritidis in neonatal broiler chicks
Higgins et al.
Poultry Science, 87, 27-31 (2008)
Yosef D Huberman et al.
Poultry science, 98(6), 2422-2431 (2019-01-29)
Salmonellosis caused by Salmonella Enteritidis is a widespread zoonosis and poultry products are an important source of infection. This study was carried out to evaluate the protection of different vaccination schedules in layers using a live commercial attenuated Salmonella Enteritidis
Margarita A Arreguin-Nava et al.
Animals : an open access journal from MDPI, 9(9) (2019-09-20)
The effect of Lactobacillus spp.-based probiotic candidates on Salmonella enterica serovar Enteritidis (SE) colonization was evaluated in two separate experiments. In each experiment, sixty-one day-of-hatch female turkey poults were obtained from a local hatchery. In both experiments, poults were challenged
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持