N170
NS 1619
powder
别名:
1,3-二氢-1- [2-羟基-5-（三氟甲基）苯基]-5-（三氟甲基）-2H-苯并咪唑-2-酮
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关于此项目
经验公式（希尔记法）:
C15H8F6N2O2
化学文摘社编号:
分子量:
362.23
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
form
powder
Quality Level
color
white
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL, ethanol: 26.6 mg/mL, 0.1 M NaOH: 5.2 mg/mL, DMSO: 5.3 mg/mL, H2O: insoluble
SMILES string
Oc1ccc(cc1N2C(=O)Nc3cc(ccc23)C(F)(F)F)C(F)(F)F
InChI
1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
InChI key
YLFMCMWKHSDUCT-UHFFFAOYSA-N
Gene Information
mouse ... Kcnma1(16531)
rat ... Kcnma1(83731)
Application
NS 1619 已被用作钙激活钾通道(BK)-激活剂：研究其对小鼠胸主动脉环的血管舒张作用，评估其对骨骼肌肌浆/内质网Ca2+-ATP酶（SERCA）活性的作用，测定其对小鼠脑肿瘤微血管内皮细胞中caveolin-1 蛋白表达的作用
Biochem/physiol Actions
NS 1619 是选择性大电导 Ca 2+ 激活的 K + 通道激活剂。该化合物以其血管扩张属性抗增殖特性而闻名。研究表明，NS 1619 对心肌缺血再灌注损伤具有保护作用。
NS-1619可以促进心肌细胞中线粒体活性氧（ROS）的形成。它可增加培养的脑片中ROS的形成。NS-1619具有增强野生型（WT）动物中HO-1活性的能力。
Disclaimer
光敏性
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Rui-Ping Cai et al.
Journal of the neurological sciences, 369, 109-118 (2016-09-23)
NS1619, a calcium-activated potassium channel (Kca channel) activator, can selectively and time-dependently accelerate the formation of transport vesicles in both the brain tumor capillary endothelium and tumor cells within 15min of treatment and then increase the permeability of the blood-brain
Rupal P Soder et al.
European journal of pharmacology, 670(1), 252-259 (2011-09-15)
Large conductance voltage- and Ca(2+)-activated K(+) (BK) channels are important in regulating detrusor smooth muscle (DSM) function. Here, we examined systematically how the BK channel pharmacological activation modulates DSM contractility. NS1619, a potent BK channel activator, was utilized as a
Antoni Wrzosek
Cell calcium, 56(1), 14-24 (2014-05-13)
NS1619 (1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazole-2-one) is widely used as a large-conductance Ca(2+)-activated K(+) (BKCa) channel opener. It was previously reported that activation of BKCa channels by NS1619 could protect the cardiac muscle against ischaemia and reperfusion injury. This study reports the effects of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N170-25MG | 04061834109716 |
| N170-5MG | 04061833621578 |