N170
NS 1619
powder
别名:
1,3-二氢-1- [2-羟基-5-（三氟甲基）苯基]-5-（三氟甲基）-2H-苯并咪唑-2-酮
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关于此项目
经验公式（希尔记法）:
C15H8F6N2O2
化学文摘社编号:
分子量:
362.23
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
表单
powder
颜色
white
溶解性
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL
ethanol: 26.6 mg/mL
0.1 M NaOH: 5.2 mg/mL
DMSO: 5.3 mg/mL
H2O: insoluble
SMILES字符串
Oc1ccc(cc1N2C(=O)Nc3cc(ccc23)C(F)(F)F)C(F)(F)F
InChI
1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
InChI key
YLFMCMWKHSDUCT-UHFFFAOYSA-N
基因信息
mouse ... Kcnma1(16531)
rat ... Kcnma1(83731)
相关类别
应用
NS 1619 已被用作钙激活钾通道(BK)-激活剂：研究其对小鼠胸主动脉环的血管舒张作用，评估其对骨骼肌肌浆/内质网Ca2+-ATP酶（SERCA）活性的作用，测定其对小鼠脑肿瘤微血管内皮细胞中caveolin-1 蛋白表达的作用
生化/生理作用
NS 1619 是选择性大电导 Ca 2+ 激活的 K + 通道激活剂。该化合物以其血管扩张属性抗增殖特性而闻名。研究表明，NS 1619 对心肌缺血再灌注损伤具有保护作用。
NS-1619可以促进心肌细胞中线粒体活性氧（ROS）的形成。它可增加培养的脑片中ROS的形成。NS-1619具有增强野生型（WT）动物中HO-1活性的能力。
免责声明
光敏性
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
S P Olesen et al.
European journal of pharmacology, 251(1), 53-59 (1994-01-04)
Activators and blockers of specific ion channels are important pharmacological tools for characterizing ion channels and their influence on cell function. The large-conductance Ca(2+)-dependent K+ channel (BK channel) is blocked by peptides such as charybdotoxin and iberiotoxin, but no selective
Inhalation of the BKCa-Opener NS1619 Attenuates Right Ventricular Pressure and Improves Oxygenation in the Rat Monocrotaline Model of Pulmonary Hypertension
Marc R
PLoS ONE (2014)
Vincenzo Calderone et al.
Naunyn-Schmiedeberg's archives of pharmacology, 375(1), 73-80 (2007-01-05)
Large-conductance calcium-activated potassium channels (BK) of smooth muscle play a role in the relevant modulation of vascular tone, due to their calcium- and voltage-dependent mechanisms of activation. A potential role of endothelial BK channels has also been suggested by approaches
Yajun Liu et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(1), G44-G54 (2011-09-17)
The objectives of this study were to determine whether neutrophil depletion with anti-neutrophil serum (ANS) or preconditioning with the hydrogen sulfide (H(2)S) donor NaHS (NaHS-PC) 24 h prior to ischemia-reperfusion (I/R) would prevent postischemic mitochondrial dysfunction in rat intestinal mucosa
The potassium channel opener NS1619 modulates calcium homeostasis in muscle cells by inhibiting SERCA
Antoni Wrzosek
Cell Calcium (2014)
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