N171
NBQX 水合物
powder, ≥98% (HPLC)
别名:
1,2,3,4-四氢-6-硝基-2,3-二氧代苯并[f]喹喔啉-7-磺酰胺 水合物, FG 9202
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关于此项目
经验公式（希尔记法）:
C12H8N4O6S · xH2O
化学文摘社编号:
分子量:
336.28 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
NBQX 水合物, powder, ≥98% (HPLC)
InChI
1S/C12H8N4O6S.H2O/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);1H2
SMILES string
O.NS(=O)(=O)c1cccc2c3NC(=O)C(=O)Nc3cc([N+]([O-])=O)c12
InChI key
VOYWRRFTJLCIEL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
methanol: 0.25 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.5 mg/mL
DMSO: 4 mg/mL
H2O: insoluble
Quality Level
Application
NBQX 水合物已用于:
- 作为非NN-甲基-D-天冬氨酸受体 (NMDA)的 2-氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA) 受体拮抗剂用于监测促性腺激素反应
- α单核细胞中的-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体 (AMPAR) 拮抗剂
- 在表达氯化钾共转运蛋白(shKCC2)的迁移中间神经元中的AMPA 和 N-甲基-D-天冬氨酸受体 (NMDA) 拮抗剂
Biochem/physiol Actions
NBQX [2,3-二羟基-6-硝基-7-氨基磺酰基苯并（F）喹喔啉]是一种抗惊厥药，可防止脊髓挤压伤中的白质损伤，并在实验性自身免疫性脑脊髓炎（EAE）中保护少突胶质细胞。然而，其在预防EAE中炎症的作用尚不清楚。
神经保护AMPA/红藻氨酸谷氨酸受体拮抗剂。
General description
NBQX [2,3-二羟基-6-硝基-7-氨基磺酰基苯并（F）喹喔啉]是一种竞争性拮抗剂，其对2-氨基-3-羟基-5-甲基-4-异恶唑丙酸（ AMPA）受体的亲和力要比钾盐镁矾受体高。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Jinwen Xue et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(46), e2207545119-e2207545119 (2022-11-08)
The neurobiological understanding of obsessive-compulsive disorder (OCD) includes dysregulated frontostriatal circuitry and altered monoamine transmission. Repetitive stereotyped behavior (e.g., grooming), a featured symptom in OCD, has been proposed to be associated with perturbed dopamine (DA) signaling. However, the precise brain
D Pitt et al.
Nature medicine, 6(1), 67-70 (1999-12-29)
Glutamate excitotoxicity mediated by the AMPA/kainate type of glutamate receptors damages not only neurons but also the myelin-producing cell of the central nervous system, the oligodendrocyte. In multiple sclerosis, myelin, oligodendrocytes and some axons are lost as a result of
Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR
Nowak W, et al.
EBioMedicine, 50, 290-305 (2019)
Jane E Libbey et al.
Experimental neurology, 280, 89-96 (2016-04-14)
Seizures occur due to an imbalance between excitation and inhibition, with the balance tipping towards excitation, and glutamate is the predominant excitatory neurotransmitter in the central nervous system of mammals. Since upregulation of expression and/or function of glutamate receptors can
Glutamate excitotoxicity in a model of multiple sclerosis
Pitt D, et al.
Nature Medicine, 6(1), 67-70 (2000)
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