N1790
Naftifine hydrochloride
别名:
Naftifine HCL
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关于此项目
经验公式（希尔记法）:
C21H21N · HCl
化学文摘社编号:
分子量:
323.86
MDL编号:
UNSPSC代码:
51102829
PubChem化学物质编号:
NACRES:
NA.76
方案
≥99%
质量水平
表单
powder
溶解性
ethanol: soluble 50 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
fungi
yeast
作用机制
cell wall synthesis | interferes
enzyme | inhibits
储存温度
2-8°C
SMILES字符串
Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
InChI
1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
InChI key
OLUNPKFOFGZHRT-YGCVIUNWSA-N
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应用
Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.
生化/生理作用
Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.
Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.
其他说明
Keep container tightly closed in a dry and well-ventilated place.Light sensitive.
储存分类代码
11 - Combustible Solids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Allergic contact dermatitis to naftifine.
Monica Corazza et al.
Contact dermatitis, 53(5), 302-303 (2005-11-15)
Muhterem Polat et al.
Mycoses, 50(6), 525-526 (2007-10-20)
The patient we present herein is a 6-month-old infant who had erythema and scaling on the central part of the face for 4 months. Both the abundant scaling and the localisation, but also the low age of this infant led
Athlete's foot.
Fay Crawford
Clinical evidence, (11)(11), 2128-2132 (2005-01-18)
Lawrence Charles Parish et al.
Journal of drugs in dermatology : JDD, 10(10), 1142-1147 (2011-10-05)
Naftifine HCl 2% cream (NAFT-2%) is a topical allylamine antifungal preparation under development in the U.S. The objective of this randomized, double-blind, vehicle-controlled study was to evaluate the efficacy and safety of a two-week course of once-daily NAFT-2% vs. vehicle
Aditya K Gupta et al.
Journal of cutaneous medicine and surgery, 12(2), 51-58 (2008-03-19)
Naftifine is a topical allylamine that is effective and safe in the management of superficial dermatomycoses. Naftifine is fungicidal in vitro against a broad spectrum of dermatophyte fungi and provides good activity against Candida and Aspergillus species. It is also
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