N1905
神经营养因子-3 人
recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, >97% (SDS-PAGE)
别名:
HDNF, NTF3, NT-3
产品名称
神经营养因子-3 人, recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, >97% (SDS-PAGE)
biological source
human
recombinant
expressed in baculovirus infected Sf21 cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
1-40 ng/mL EC50
packaging
pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... NTF3(4908)
Analysis Note
使用TrkB转染的细胞系BaF-TrkB-BD在细胞增殖测定中测量生物学活性。
Application
人神经营养蛋白-3已用于少突胶质祖细胞的磁性分选。
Biochem/physiol Actions
神经营养蛋白-3（13.6 kDa或27.2 kDa二聚体）是神经营养蛋白家族的成员。其在人、小鼠和猪中具有相同的氨基酸序列，具有完全的交叉反应性。 NT-3在神经元群体的发育和维持中很重要，并促进神经嵴衍生的感觉和交感神经元的分化。这对于本体感受的1a传入神经元至关重要，后者将信息从周围的肌肉纺锤体传递到运动神经元，并将投影发送到脊髓小脑神经元。NT-3在上颈和结节神经节中也很重要。
General description
NTF3（神经营养蛋白3）是属于NGF（神经生长因子）家族的神经营养因子。该蛋白质由257个氨基酸组成，前体区为138个氨基酸，成熟序列为119个残基。
Physical form
从磷酸盐缓冲盐水(PBS)中的0.2 m过滤溶液冻干，每1μg细胞因子含有50μg牛血清白蛋白(BSA)。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Defective glial maturation in vanishing white matter disease
Bugiani M, et al.
Journal of Neuropathology and Experimental Neurology, 70(1), 69-82 (2011)
Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis
Louie E, et al.
Oncogene, 32(35), 4064-4064 (2013)
Cloning and expression of a cDNA encoding a novel human neurotrophic factor.
Kaisho Y et al
Febs Letters, 266(1-2), 187-191 (1990)
Neurotrophin 3 is a mitogen for cultured neural crest cells.
Kalcheim C et al
Proceedings of the National Academy of Sciences of the USA, 89(5), 1661-1665 (1992)
Linkage of the gene for the triple A syndrome to chromosome 12q13 near the type II keratin gene cluster
Weber A, et al.
Human Molecular Genetics, 5(12), 2061-2066 (1996)
商品
Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持