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Merck
CN

N194

Sigma-Aldrich

NS-398

≥98% (HPLC), solid

别名:

N-[2-(环己氧基)-4-硝基苯基]甲磺酰胺

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关于此项目

经验公式(希尔记法):
C13H18N2O5S
化学文摘社编号:
分子量:
314.36
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平

方案

≥98% (HPLC)

表单

solid

颜色

off-white

mp

127-128 °C

溶解性

DMSO: >5 mg/mL
H2O: insoluble

SMILES字符串

CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

InChI key

KTDZCOWXCWUPEO-UHFFFAOYSA-N

基因信息

应用

NS-398作为环氧化酶2(COX2)抑制剂,已用于研究其:
  • 对斑马鱼胚胎心率的作用
  • 对大鼠心肌细胞凋亡和缺氧/复氧的作用
  • 对大鼠脂多糖(LPS)诱导厌食的作用

生化/生理作用

NS-398属于非甾体抗炎药(NSAID)。具有抗炎、镇痛和退烧作用。
选择性环加氧酶-2(COX-2)抑制剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Jihye Jung et al.
Cells, 8(7) (2019-06-30)
The epithelial-mesenchymal transition (EMT) is important in organ fibrosis. We hypothesized that growth arrest-specific protein 6 (Gas6) and its underlying mechanisms play roles in the prevention of EMT in alveolar epithelial cells (ECs). In this study, to determine whether Gas6
Yuyin Yi et al.
Placenta, 68, 44-51 (2018-07-30)
Enhanced expression and activity of cyclooxygenase-2 (COX-2) has been reported in trophoblasts from women with preeclampsia compared with healthy pregnant women. Prostaglandin E2, the production of which is initiated by COX-2, and transforming growth factor-β1 (TGF-β1) have been shown to
N Futaki et al.
General pharmacology, 24(1), 105-110 (1993-01-01)
1. NS-398 (N-[2-cyclohexyloxy-4-nitrophenyl] methanesulfonamide) is a new non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. 2. The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac.
Pedro Cruz Duarte et al.
Experimental neurology, 234(2), 466-481 (2012-02-09)
Brain-derived neurotrophic factor (BDNF) exists in small to medium size neurons in adult rat dorsal root ganglion (DRG) and serves as a modulator at the first synapse of the pain transmission pathway in the spinal dorsal horn. Peripheral nerve injury
P Leclerc et al.
Scandinavian journal of immunology, 77(5), 350-360 (2013-03-16)
PGE2 is a potent lipid mediator of pain and oedema found elevated in RA. Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal enzyme of the PGE2 pathway inducible by proinflammatory cytokines. mPGES-1 is markedly upregulated in RA synovial tissue despite

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