N2162
NH125
≥98% (HPLC), solid
别名:
1-Benzyl-3-cetyl-2-methylimidazolium iodide
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关于此项目
经验公式（希尔记法）:
C27H45IN2
化学文摘社编号:
分子量:
524.56
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
NH125, ≥98% (HPLC), solid
InChI key
RVWOHCBHAGBLLT-UHFFFAOYSA-M
SMILES string
[I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C
InChI
1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1
assay
≥98% (HPLC)
form
solid
color
white to off-white
mp
88.2-94.9 °C
solubility
DMSO: >20 mg/mL
storage temp.
−20°C
Quality Level
Analysis Note
IC50 = 60 nM for eEF-2 kinase vs protein kinase C (IC50= 7.5 μM), protein kinase A (IC50= 80 μM), and calmodulin-dependent kinase II IC50 > 100 μM).
Biochem/physiol Actions
NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.
NH125 is a novel plant histidine kinase inhibitor and selective mammalian eurkaryotic elongation factor-2 kinase (eEF-2K).
Packaging
Packaged under nitrogen.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Tomoko Kodama et al.
The Journal of veterinary medical science, 81(1), 35-41 (2018-11-16)
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) inhibits protein translation through the phosphorylation of its specific substrate, eEF2. We previously demonstrated that eEF2K expression increases in superior mesenteric artery from spontaneously hypertensive rats (SHR) and that eEF2K mediates development of
Chih-Hua Chang et al.
Neuropharmacology, 143, 95-105 (2018-09-24)
When faced with stressful conditions, people with a tendency toward impulsive aggression may suddenly hurt others. We have previously shown that the blockade of NMDA receptors (NMDARs) within the ventral hippocampus (VH) produces anti-aggressive effects. However, little is known about
Tao Ma et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12230-12238 (2014-09-05)
The AMP-activated protein kinase (AMPK) is a Ser/Thr kinase that is activated in response to low-energy states to coordinate multiple signaling pathways to maintain cellular energy homeostasis. Dysregulation of AMPK signaling has been observed in Alzheimer's disease (AD), which is
Yuan-Yuan Zhao et al.
Drug design, development and therapy, 12, 2655-2663 (2018-09-15)
Our previous research showed that AKT inactivation via small molecule inhibitors did not induce significant apoptosis, but rather markedly increased autophagy in nasopharyngeal carcinoma (NPC). The purpose of the current study was to determine whether autophagy inhibition can enhance the
Zehan Chen et al.
The Journal of biological chemistry, 286(51), 43951-43958 (2011-10-25)
Eukaryotic elongation factor-2 kinase (eEF2K) relays growth and stress signals to protein synthesis through phosphorylation and inactivation of eukaryotic elongation factor 2 (eEF2). 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) is a widely accepted inhibitor of mammalian eEF2K and an efficacious anti-proliferation agent against
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