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N2286

无活菌素

Name: 无活菌素
Brand: SIGMA

from Streptomyces griseus, ≥98.0% (Total homologs, HPLC)

别名:

铵离子载体

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关于此项目

经验公式（希尔记法）:

C₄₀H₆₄O₁₂

化学文摘社编号:

6833-84-7

分子量:

736.93

NACRES:

NA.76

PubChem Substance ID:

24897566

UNSPSC Code:

51102829

EC Number:

229-911-3

Beilstein/REAXYS Number:

76434

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属性

biological source

Streptomyces griseus

Quality Segment

300

description

Natural macrotetrolide, may contain homologues (like monactin and dinactin)

assay

≥98.0% (Total homologs, HPLC)

form

powder

solubility

chloroform: soluble 10 mg/mL

antibiotic activity spectrum

Gram-positive bacteria

mode of action

DNA synthesis | interferes, cell membrane | interferes

storage temp.

2-8°C

SMILES string

C[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1

InChI

1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-

InChI key

RMIXHJPMNBXMBU-QIIXEHPYSA-N

说明

General description

Chemical structure: macrolide

Application

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation .

Biochem/physiol Actions

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, and to inhibit surface expression of certain heat shock proteins (HSP60) .

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

存储类别

11 - Combustible Solids

WGK

WGK 3

闪点 (F)

Not applicable

闪点 (°C)