N2288
Nefiracetam
solid
别名:
(2-(2-oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide), DM-9384
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C14H18N2O2
化学文摘社编号:
分子量:
246.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
SMILES string
Cc1cccc(C)c1NC(=O)CN2CCCC2=O
InChI key
NGHTXZCKLWZPGK-UHFFFAOYSA-N
form
solid
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
color
white to off-white
solubility
DMSO: >5 mg/mL
Quality Level
Biochem/physiol Actions
Nefiracetam (NEF) is a pyrrolidonetype nootropic agent with various pharmacologic as well as cognition enhancing effects. In amygdala-kindled seizures, nefiracetam inhibits both electroencephalographic and behavioral seizures. NEF has a distinct anticonvulsant spectrum.
Novel pyrrolidonetype nootropic (condition enhancing) agent with anticonvulsant spectrum.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Yoshimi Tsuchiya et al.
Archives of toxicology, 79(9), 500-507 (2005-07-12)
The occurrence of renal papillary necrosis (RPN), seen only in dogs after repeated oral administration of nefiracetam, a neurotransmission enhancer, at a relatively high dose, is because of inhibition of renal prostaglandin synthesis by the nefiracetam metabolite M-18. In this
S Moriguchi et al.
Neuroscience, 160(2), 484-491 (2009-03-11)
The cholinergic and glutamatergic systems are known to be downregulated in the brain of Alzheimer's disease patients. Galantamine and nefiracetam have been shown to potentiate the phasic activity of nicotinic acetylcholine receptors (nAChRs) in the brain. Stimulation of nAChRs is
Xavier Buol et al.
Pharmaceutics, 12(7) (2020-07-15)
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully
Yutaka Kitano et al.
Brain research, 1057(1-2), 168-176 (2005-08-27)
Nefiracetam is a novel pyrrolidone-type nootropic agent, and it has been reported to possess a potential for antiepileptic therapy as well as cognition-enhancing effects. We investigated the anticonvulsant and neuroprotective effects of nefiracetam in kainic acid-induced seizures of rats, compared
Yutaka Kitano et al.
Epilepsia, 46(10), 1561-1568 (2005-09-30)
Nefiracetam (NEF) is a novel pyrrolidonetype nootropic agent, and it has been reported to possess various pharmacologic effects as well as cognition-enhancing effects. The present study focused on the effects of NEF in amygdala-kindled seizures and its potential for antiepileptic
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持