N2290
NP603
≥98% (HPLC)
别名:
(Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, 5-[[6-(3,5-Dimethoxyphenyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
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关于此项目
经验公式（希尔记法）:
C26H26N2O5
化学文摘社编号:
分子量:
446.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
assay
≥98% (HPLC)
form
powder
color
orange-red
solubility
DMSO: ≥30 mg/mL
storage temp.
2-8°C
SMILES string
COc1cc(OC)cc(c1)-c2ccc3c(NC(=O)\C3=C/c4[nH]c(C)c(CCC(O)=O)c4C)c2
InChI
1S/C26H26N2O5/c1-14-20(7-8-25(29)30)15(2)27-23(14)13-22-21-6-5-16(11-24(21)28-26(22)31)17-9-18(32-3)12-19(10-17)33-4/h5-6,9-13,27H,7-8H2,1-4H3,(H,28,31)(H,29,30)/b22-13-
InChI key
ZIZSHSPAAJIYOD-XKZIYDEJSA-N
Biochem/physiol Actions
NP603 is a cell-permeable inhibitor of PDGFRβ, FGFR1 and VEGFR2 that binds to ATP pocket.
NP603 is a cell-permeable inhibitor of PDGFRβ, FGFR1 and VEGFR2 that binds to ATP pocket. NP603 is a very weak inhibitor of EGFR (IC50 >100 μM).
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the FGFR and PDGFR pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
WGK
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable